2022
DOI: 10.1007/s00221-022-06519-z
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Up-regulation of lncRNA NEAT1 in cerebral ischemic stroke promotes activation of astrocytes by modulation of miR-488-3p/RAC1

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Cited by 7 publications
(6 citation statements)
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“… 58 Hsa-miR-488-3p is also involved in regulating the activation of astrocytes in IS. 59 In this study, we also found that hsa-miR-3150b-3p, hsa-miR-541-5p, hsa-miR-184 and hsa-miR-488-3p were abnormally expressed in IS. Therefore, we speculate that hsa-miR-3150b-3p, hsa-miR-541-5p, hsa-miR-184 and hsa-miR-488-3p may target the regulation of RRAS2, PPM1B, CLDN7 and ADCY3 in the progression of IS.…”
Section: Discussionsupporting
confidence: 64%
“… 58 Hsa-miR-488-3p is also involved in regulating the activation of astrocytes in IS. 59 In this study, we also found that hsa-miR-3150b-3p, hsa-miR-541-5p, hsa-miR-184 and hsa-miR-488-3p were abnormally expressed in IS. Therefore, we speculate that hsa-miR-3150b-3p, hsa-miR-541-5p, hsa-miR-184 and hsa-miR-488-3p may target the regulation of RRAS2, PPM1B, CLDN7 and ADCY3 in the progression of IS.…”
Section: Discussionsupporting
confidence: 64%
“…Another noteworthy example of a PhenomeX substance use-linked candidate gene with altered expression in all three major glial prototypes, including astrocytes, microglia and ODC/OPC (Fig. 5 ) is the nuclear paraspeckles-associated long non-coding RNA, NEAT1 , which has been broadly linked to astrocytic and microglial activation 50 , 51 , and has been previous reported as up-regulated in ventral striatum of heroin abusers 52 . Consistent with these findings, multiple inflammatory response- and cell activation- and migration-associated GOs involving NEAT1 , and additional PhenomeX substance use associated glial DEGs such as ATP1B3 , BARD1 and HESX1 were significantly enriched among the glial DEGs of the present study (Fig.…”
Section: Resultsmentioning
confidence: 98%
“…9h). 122,123 We identified regulatory networks involving 12 lncRNAs, 16 miRNAs, and 6 mRNAs that play critical roles in PD. By elucidating the regulatory interactions within this network, researchers can uncover novel pathways and processes involved in disease development and progression.…”
Section: Discussionmentioning
confidence: 99%