Up-regulation of insulin receptors with dexamethasone in cultured human urinary bladder carcinoma cells.

Human adipocytes from patients with chronic endogenous hypercortisolism (Cushing's syndrome) showed a statistically significant decrease in insulin binding at low unlabelled-insulin concentrations but no change in receptor numbers (Cushing's 180,000 +/- 48,000 (3) receptors/cell and controls 189,000 +/- 30,000 (7)) together with a fourfold decrease in apparent receptor affinity (ED50: Cushing's 2.25 x 10(-9) M and controls 0.57 x 10(-9) M) and a decreased sensitivity to the antilipolytic effect of insulin. These events could represent the final situation of a chronic and endogenous regulation by high levels of cortisol of insulin receptors in human adipose tissue.

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Decreased insulin binding and antilipolytic response in adipocytes from patients with Cushing's syndrome

Calle

Carranza

Simón

et al. 1987

Bioscience Reports

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Modulation by dexamethasone of insulin binding and insulin receptor mRNA levels in U-937 human promonocytic cells

Leal¹,

Cabañas²,

Rı́us³

et al. 1992

Biochimie

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Insulin Use and Smoking Jointly Increase the Risk of Bladder Cancer Mortality in Patients With Type 2 Diabetes

Tseng

2013

Clinical Genitourinary Cancer

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Up-regulation of insulin receptors with dexamethasone in cultured human urinary bladder carcinoma cells.

Cited by 7 publications

References 20 publications

Decreased insulin binding and antilipolytic response in adipocytes from patients with Cushing's syndrome

Decreased insulin binding and antilipolytic response in adipocytes from patients with Cushing's syndrome

Modulation by dexamethasone of insulin binding and insulin receptor mRNA levels in U-937 human promonocytic cells

Insulin Use and Smoking Jointly Increase the Risk of Bladder Cancer Mortality in Patients With Type 2 Diabetes

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