Up-Conversion Luminescence System for Quantitative Detection of IL-6

Chu, Zhengkang; Jie, Guo; Guo, Jun

doi:10.1109/tnb.2022.3178754

Cited by 3 publications

(1 citation statement)

References 19 publications

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“… 169 Furthermore, Chu et al have established a UCL system based on UCNPs for rapid and accurate quantification of IL-6, offering the potential for early diagnosis of inflammatory GI diseases. 170 Thus, UCNP-based luminescence imaging utilizing the “optical window” provided by UCNPs holds great promise for effective imaging of GI diseases.…”

Section: Key Nps In Gi Diseases Imagingmentioning

confidence: 99%

Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective

Yue¹,

Xu²,

Xu³

et al. 2023

IJN

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The diagnosis of gastrointestinal (GI) diseases currently relies primarily on invasive procedures like digestive endoscopy. However, these procedures can cause discomfort, respiratory issues, and bacterial infections in patients, both during and after the examination. In recent years, nanomedicine has emerged as a promising field, providing significant advancements in diagnostic techniques. Nanoprobes, in particular, offer distinct advantages, such as high specificity and sensitivity in detecting GI diseases. Integration of nanoprobes with advanced imaging techniques, such as nuclear magnetic resonance, optical fluorescence imaging, tomography, and optical correlation tomography, has significantly enhanced the detection capabilities for GI tumors and inflammatory bowel disease (IBD). This synergy enables early diagnosis and precise staging of GI disorders. Among the nanoparticles investigated for clinical applications, superparamagnetic iron oxide, quantum dots, single carbon nanotubes, and nanocages have emerged as extensively studied and utilized agents. This review aimed to provide insights into the potential applications of nanoparticles in modern imaging techniques, with a specific focus on their role in facilitating early and specific diagnosis of a range of GI disorders, including IBD and colorectal cancer (CRC). Additionally, we discussed the challenges associated with the implementation of nanotechnology-based GI diagnostics and explored future prospects for translation in this promising field.

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Section: Key Nps In Gi Diseases Imagingmentioning

confidence: 99%

Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective

Yue¹,

Xu²,

Xu³

et al. 2023

IJN

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Sensitive detection of exhaled breath condensate inflammation biomarkers using boron nitride nanosheet/gold nanoparticle hybrids

Zhang,

Li,

Yang

et al. 2024

Alexandria Engineering Journal

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Ratiometric Electrochemical Detection of Interleukin-6 Using Electropolymerized Methylene Blue and a Multi-Walled Carbon-Nanotube-Modified Screen-Printed Carbon Electrode

Liu,

Wang

et al. 2024

Biosensors

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Herein, we report a ratio-based electrochemical biosensor for the detection of interleukin-6 (IL-6). We electropolymerized methylene blue (MB) on the surface of screen-printed carbon electrodes; introduced an internal reference signal probe; modified the carboxylate multi-walled carbon nanotubes on the electrode surface to increase the electrochemically active area; and finally linked the amino-modified IL-6 aptamer to the electrode surface through the Schiff base reaction, with bovine serum albumin (BSA) added to mask non-specific adsorption. After adding IL-6 to the samples, the signal of IMB remained almost unchanged, while the signal of I[Fe(CN)6]3−/4− decreased with increasing IL-6 concentration. Thus, a novel ratiometric electrochemical sensor with a linear range of 0.001~1000.0 ng/mL and a low detection limit of 0.54 pg/mL was successfully developed. The sensor had high repeatability, stability, sensitivity, and practicability. It provides a new method for constructing proportional electrochemical sensors and detecting IL-6.

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Up-Conversion Luminescence System for Quantitative Detection of IL-6

Cited by 3 publications

References 19 publications

Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective

Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective

Sensitive detection of exhaled breath condensate inflammation biomarkers using boron nitride nanosheet/gold nanoparticle hybrids

Ratiometric Electrochemical Detection of Interleukin-6 Using Electropolymerized Methylene Blue and a Multi-Walled Carbon-Nanotube-Modified Screen-Printed Carbon Electrode

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