Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective

Abstract

The diagnosis of gastrointestinal (GI) diseases currently relies primarily on invasive procedures like digestive endoscopy. However, these procedures can cause discomfort, respiratory issues, and bacterial infections in patients, both during and after the examination. In recent years, nanomedicine has emerged as a promising field, providing significant advancements in diagnostic techniques. Nanoprobes, in particular, offer distinct advantages, such as high specificity and sensitivity in detecting GI diseases. Integration of nanoprobes with advanced imaging techniques, such as nuclear magnetic resonance, optical fluorescence imaging, tomography, and optical correlation tomography, has significantly enhanced the detection capabilities for GI tumors and inflammatory bowel disease (IBD). This synergy enables early diagnosis and precise staging of GI disorders. Among the nanoparticles investigated for clinical applications, superparamagnetic iron oxide, quantum dots, single carbon nanotubes, and nanocages have emerged as extensively studied and utilized agents. This review aimed to provide insights into the potential applications of nanoparticles in modern imaging techniques, with a specific focus on their role in facilitating early and specific diagnosis of a range of GI disorders, including IBD and colorectal cancer (CRC). Additionally, we discussed the challenges associated with the implementation of nanotechnology-based GI diagnostics and explored future prospects for translation in this promising field.

Nanodrug delivery materials for digestive system diseases

“…Thus, NP-based diagnostic techniques can enable the early diagnosis, as well as precise staging, of GI diseases. 107 However, the nanotechnology still faces challenges in clinical applications, such as the stability, biocompatibility, and large-scale preparation of NPs. Future studies should comprehensively explore these issues to realize the widespread implementation of the nanotechnology in GI illness diagnostics.…”

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

“…Additionally, ongoing research is exploring the use of nanomaterials for diagnostic purposes, such as imaging and sensing techniques, further expanding their potential in the field of medicine . Nanotechnology holds promise to treat many chronic diseases, which include cardiovascular, neurological, gastrointestinal, autoimmune inflammatory, infectious, and reproductive diseases, as well as various types of cancer …”

“…Additionally, ongoing research is exploring the use of nanomaterials for diagnostic purposes, such as imaging and sensing techniques, 7 further expanding their potential in the field of medicine. 8 Nanotechnology holds promise to treat many chronic diseases, which include cardiovascular, 9 neurological, 10 gastrointestinal, 11 autoimmune inflammatory, 12 infectious, 13 and reproductive diseases, 14 as well as various types of cancer. 15 With the help of nanoscience, reproductive assistive technology has revolutionized the field of fertility treatments, and scientists have been able to develop innovative methods that improve the success rates of procedures such as in vitro fertilization (IVF) and sperm selection by utilizing nano-technology.…”