UP-3.135: COM Crystals Stimulate the Expression and Activity of NADPH Oxidase in Macrophage

Deng, Yaoliang; Sun, Bin; Li, C.

doi:10.1016/j.urology.2009.07.140

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“…At the same time, the crystals can promote the expression of NADPH oxidase in the cell to generate a large amount of ROS, induce the nuclear factor kB signal transduction pathway, and produce a great amount of inflammatory factors including TNF-a, IL -6, and IL-1b. This further causes inflammatory damage to kidney cells, leading to cell degeneration, necrosis, exposure of basement membrane, etc., which is conducive to the formation of renal calcification plaques (39,40). In the hyperoxaluria rat model, hyperoxaluria can activate the NF-kB signal transduction pathway through ROS, induce the kidney to express a great amount of inflammatory factors including MCP-1, IL-6, and IL-1b.…”

Section: Ros-induced Activation Of Nlrp3 In Macrophage-crystal Reactionmentioning

confidence: 99%

Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis

et al. 2022

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Calcium oxalate nephrolithiasis is a common and highly recurrent disease in urology; however, its precise pathogenesis is still unknown. Recent research has shown that renal inflammatory injury as a result of the cell-crystal reaction plays a crucial role in the development of calcium oxalate kidney stones. An increasing amount of research have confirmed that inflammation mediated by the cell-crystal reaction can lead to inflammatory injury of renal cells, promote the intracellular expression of NADPH oxidase, induce extensive production of reactive oxygen species, activate NLRP3 inflammasome, discharge a great number of inflammatory factors, trigger inflammatory cascading reactions, promote the aggregation, nucleation and growth process of calcium salt crystals, and ultimately lead to the development of intrarenal crystals and even stones. The renal tubular epithelial cells (RTECs)-crystal reaction, macrophage-crystal reaction, calcifying nanoparticles, endoplasmic reticulum stress, autophagy activation, and other regulatory factors and mechanisms are involved in this process.

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Section: Ros-induced Activation Of Nlrp3 In Macrophage-crystal Reactionmentioning

confidence: 99%

Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis

et al. 2022

View full text Add to dashboard Cite

show abstract

UP-3.135: COM Crystals Stimulate the Expression and Activity of NADPH Oxidase in Macrophage

Cited by 1 publication

References 0 publications

Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis

Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis

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