UP-01.164: Laparoscopic Nephrectomy for Renal Arterial Stenosis in Autotransplantation

Tran, N.S.; Duong, Q.V.; Thái, Minh Sâm; Th, K.C. Duong; Ng, Th. Du Th; Chau, Q.Th.; Kh, Ch. Hoang; Tr, Tr. Tran; Th, Howell

doi:10.1016/j.urology.2009.07.611

Cited by 2 publications

(2 citation statements)

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“…The gardi-mPDA treated mice showed moderate inhibition in tumor growth, which is possibly due to the reversal of immuno-suppressive microenvironment in tumor caused by TLR7/8 agonism in DCs. 51 Moderate inhibition of tumor growth after treatment with gardiquimod has been observed previously. [42][43] More specifically gardiquimod is known to impart tumor-killing potential to plasmacytoid dendritic cells.…”

Section: In Vivo Therapeutic Efficacy Of Gardi-mpdamentioning

confidence: 75%

Polydopamine–Mesoporous Silica Core–Shell Nanoparticles for Combined Photothermal Immunotherapy

Seth

Derami

Gupta

et al. 2020

ACS Appl. Mater. Interfaces

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Cancer immunotherapy involves a cascade of events that ultimately leads to cytotoxic immune cells effectively identifying and destroying cancer cells. Responsive nanomaterials, which enable spatiotemporal orchestration of various immunological events for mounting a highly potent and long-lasting anti-tumor immune response, are an attractive platform to overcome challenges associated with existing cancer immunotherapies. Here, we report a multifunctional near infrared (NIR)-responsive core-shell nanoparticle, which enables (i) photothermal ablation of cancer cells for generating tumor associated antigen (TAA) and (ii) triggered release of an immunomodulatory drug (gardiquimod) for starting a series of immunological events. The core of these nanostructures is composed of polydopamine nanoparticle, which serves as a photothermal agent, and the shell is made of mesoporous silica, which serves as a drug carrier. We employed a phase-change material as gatekeeper to achieve concurrent release of both TAA and adjuvant, thus efficiently activating the antigen presenting cells (APCs). Photothermal-immunotherapy enabled by these nanostructures resulted in regression of primary tumor and significantly improved inhibition of secondary tumor in a mouse melanoma model. These biocompatible, biodegradable, and NIRresponsive core-shell nanostructures simultaneously deliver payload and cause photothermal *

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Section: In Vivo Therapeutic Efficacy Of Gardi-mpdamentioning

confidence: 75%

Polydopamine–Mesoporous Silica Core–Shell Nanoparticles for Combined Photothermal Immunotherapy

Seth

Derami

Gupta

et al. 2020

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Therefore, exosomes contain specific proteins and nucleic acids and represent their parent cell status and functions at the time of formation [13][14] . Among many subtypes of exosomes, immunogenic exosomes with an intrinsic payload of MHC class I and II molecules and other co-stimulatory molecules are able to mediate immune responses [15][16] , which opens up opportunities for the development of novel cancer vaccines and delivery in immunotherapy [17][18][19][20][21][22][23][24][25][26] .…”

Section: Introductionmentioning

confidence: 99%