Unusually very late-onset new growth of intraocular retinoblastoma: A case report and review of literature

Gelaw, Yeshigeta; Shoukry, Shoeib Mohamed; Othman, Ihab Saad

doi:10.1016/j.ajoc.2016.12.013

Cited by 5 publications

(6 citation statements)

References 16 publications

(31 reference statements)

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“…This finding is consistent with a study conducted in the USA (34%, 95% CI: 25.7–43.4) with a median follow‐up of 5 years 24 . Another study found that a new growth of intraocular RB can occur more than 10 years after the eye responds to conservative treatment 30 . Therefore, a long‐term follow‐up of RB eyes, especially bilateral RB that receives conservation therapy, is essential.…”

Section: Discussionsupporting

confidence: 89%

Conservative treatment using laser diode and systemic chemotherapy for early‐stage bilateral retinoblastoma: A 14‐year prospective cohort study

Phan,

Derumigny,

Duong

et al. 2023

Cancer Reports

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BackgroundSolid evidence of the safety and effectiveness of retinoblastoma (RB) conservative treatment using thermotherapy and systemic chemotherapy with long‐term follow‐up is scarce, especially in low‐resource countries.AimsThis study examined the outcomes of this treatment and associated predictors in Vietnam to strengthen the current RB treatment protocol focusing on preserving eye and vision in low‐resource settings.Methods and resultsA prospective cohort study was conducted at Ho Chi Minh City Eye Hospital in Vietnam from 2005 to 2019. All eligible patients with bilateral RB (one eye already removed and another eye classified as group A or B) and without previous treatment were recruited. All patients received thermotherapy and six cycles of systemic three‐agent chemotherapy repeated every 4 weeks. A standardized questionnaire was used to collect information on study participants' age, symptoms, tumor characteristics, treatment, and outcomes. Among 50 eyes of all 50 patients with a median age of 9 (4–20) months, 34 eyes were in group B (68%). The median follow‐up time was 60 (60–84) months. All 139 preserved tumors regressed mostly to type 4 (70.4%) and type 3 (23.7%) scars. Kaplan–Meier analysis found the overall globe‐salvage rate at 5 years of 91.9% (95% CI: 80.1%–97.7%). Most eyes (41/50, 82%, 95% CI: 69.2%–90.2%) had a final visual acuity ≥0.1. The visual acuity is higher when tumors regressed to a type 4 scar (p = .007, AOR = 8.098, 95% CI: 1.79–36.53) which also shows less enucleation than a type 3 scar (p = .002, AOR = 0.06, 95% CI: 0.01–0.37%). Gender effect on visual acuity after treatment was significant and may be due to discrimination. No major complications were recorded.ConclusionConservative treatment of early‐stage RB is safe and effective. Long‐term, thorough follow‐ups of patients post‐treatment are needed. The regression patterns of scars could be a useful indicator of treatment failure.

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Section: Discussionsupporting

confidence: 89%

Conservative treatment using laser diode and systemic chemotherapy for early‐stage bilateral retinoblastoma: A 14‐year prospective cohort study

Phan,

Derumigny,

Duong

et al. 2023

Cancer Reports

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“…Although there are reports of tumor recurrences after several years following treatment completion, 13 nearly all retinal tumor recurrences will be presented by 3 years of follow-up. 3 Several studies have suggested younger age, especially below 2 years, at diagnosis is predictive of new tumor development.…”

Section: Recurrence: Retinalmentioning

confidence: 99%

A Review of Recurrent Retinoblastoma: Children’s Hospital Los Angeles Classification and Treatment Guidelines

Berry

Kogachi

Murphree

et al. 2019

International Ophthalmology Clinics

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“…It was difficult to differentiate regressed retinoblastoma from active recurrent retinoblastoma, due to posterior synechia and white mass precluded ophthalmoscopic visualization, even though inflammation and pain can be a warning sign of the recurrence RB. Overall, most commonly tumor regrowth appeared in the eyes of children diagnosed at a very young age or those with family history of RB 3 which is absent in the current case. We performed enucleation followed by histopathology examination to determine the diagnosis, which clarified the tissue as undifferentiated retinoblastoma, without rosettes and confirmed there was no sign of cornea, ciliary body and optic nerve attachment with the tumor (Fig 4,5).…”

Section: Case Descriptionmentioning

confidence: 46%

Blind Painful Eye Revealing Spontaneously Regressed Retinoblastoma in Young Patient

Hadijah¹,

Pagarra²,

Amir³

et al. 2021

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Purpose: Spontaneous regression is a rare but well-known feature of retinoblastoma, which is predicted in approximately 2 of every 100 cases. Unilateral, unifocal spontaneous regression of retinoblastoma is infrequent; bilateral multifocal spontaneous regression of retinoblastoma is even more extraordinary. In many of the previously reported cases, the eye (or eyes) containing the spontaneously regressed tumor has been phthisical and blind. Herein, we describe the case of a young woman with unilateral, spontaneously regressed retinoblastoma (RB), with inflamed, blind, and phthisis in the left eye as an uncommon presentation of spontaneously regressed retinoblastoma Methods: This is a case report: An 18-year-old woman came to the outpatient clinic with a chief complaint of pain in the left eye since 1 month prior and a history of dysfunctional “cat’s” eye since childhood. Results: Exotropia and atrophy bulbi was noticed in the left eye. Anterior segment examination revealed signs of inflammation including conjunctival hyperemia, shallow anterior chamber, rubeosis iridis, and posterior synechia with white “chalky” mass suggestive calcification. B-scan ultrasonography showed a point like lesion and solitary solid intraocular mass with calcification in vitreus. Orbital computed tomography scan (CT-Scan) showed atrophy of the left eye with intraocular calcification without optic nerve and extraocular muscle involvement. Enucleation and histopathology examination were done and revealed undifferentiated retinoblastoma beyond the sign of metastasis in other parts of the eye. Conclusion: Blind painful eye may present as the main feature of spontaneously regressed retinoblastoma that possibly caused by an inflammatory reaction.

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Unusually very late-onset new growth of intraocular retinoblastoma: A case report and review of literature

Cited by 5 publications

References 16 publications

Conservative treatment using laser diode and systemic chemotherapy for early‐stage bilateral retinoblastoma: A 14‐year prospective cohort study

Conservative treatment using laser diode and systemic chemotherapy for early‐stage bilateral retinoblastoma: A 14‐year prospective cohort study

A Review of Recurrent Retinoblastoma: Children’s Hospital Los Angeles Classification and Treatment Guidelines

Blind Painful Eye Revealing Spontaneously Regressed Retinoblastoma in Young Patient

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