Unusual Types of Non-Lactose-Fermenting, Gram-Negative Bacilli from Acute Diarrhea in Infants

Fothergill, Le Roy D.

doi:10.1093/infdis/45.5.393

Cited by 20 publications

(6 citation statements)

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“…Dudgeon (1924) and later Dudgeon & Pulvertaft (1937), in classifying 300 strains (of paracolon organisms on the basis of the production of gas from dulcite and saccharose, found that 860/, produced gas from dulcite but not from saccharose, most of them being serologically of the same type. Several other workers who have studied these organisms (Pisu, 1939 ;Jones, Orcutt & Little, 1932 ;Kennedy, Cumniings & Morrow, 1933: Fothergill, 1929 have found difficulty in classifying them. A series of 363 cultures of paracolon organisms was studied by Stuart et al (1043) ; they found 61 5% to resemble Bact.…”

Section: / Omentioning

confidence: 99%

The Classification of Coli‐aerogenes Bacteria Isolated From Farm Water Supplies

Thomas

Jones

Franklin

1951

Proceedings of the Society for Applied Bacteriology

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Summary: The methods suggested in the Report of the Coliform Sub‐Committee of the Society for Applied Bacteriology (Report, 1949) have been used in isolating and studying the coli‐aerogenes content of 142 samples of farm water supplies in two distinctive areas of Britain. The Gram‐negative cultures were grouped into typical, anaerogenic, non‐lactose‐fermenting and ‘unclassifiable’types, forming 54.2, 2.9, 10.9 and 32.0% of the 384 cultures respectively. Among the 261 coli‐aerogenes cultures, Bact. coli, intermediate and aerogenes‐cloacae organisms were found with frequencies of 32.2, 19.5 and 48.3% respectively. The majority of anaerogenic coli‐aerogenes organisms resembled Bact. coli type II while the predominant non‐lactose‐fermenters resembled Bact. cloacae and Bact. aerogenes type I. The reactions of 123 ‘unclassifiable'strains were such that very few could be regarded as Bact. coli types owing to the high incidence of gelatin liquefaction and growth in citrate broth.

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Section: / Omentioning

confidence: 99%

The Classification of Coli‐aerogenes Bacteria Isolated From Farm Water Supplies

Thomas

Jones

Franklin

1951

Proceedings of the Society for Applied Bacteriology

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“…Fothergill, 1929;de Roda, 1939). Two Sonne strains were isolated from sisters and a third came from an infant in the same street.…”

Section: B Types Of Organisms Isolatedmentioning

confidence: 99%

“…The report continues: 'It seemed at first that the Fothergill (1929) reluctantly suggested that the paracolon strains which he isolated from 44 % of cases in Boston caused the disease. The strains isolated by Pisu (1939), corresponding to Group I bacilli, produced a fatal enteritis in rabbits when injected intravenously.…”

Section: E Non-lactose-fermenting Bacilli Other Than B Dysenteriaementioning

confidence: 99%

“…Dugdeon (1924) and later Dudgeon & Pulvertaft (1927) classified 300 strains on the basis of the fermentation of dulcite and saccharose, 86 % fermenting dulcite but not saccharose and most of these were serologically of the same type (Group A). Numerous other workers (Pisu, 1939;Jones, Orcult & Little, 1931;Kennedy, Cummings and Morrow, 1932;Fothergill, 1929), who have studied these organisms, have found difficulty in classifying them.…”

Section: Introductionmentioning

confidence: 99%

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Bacteriological investigation into the causation of diarrhoea and enteritis in Dublin in 1942—3

Sevitt

1945

J. Hyg.

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The Group I paracolon bacilli formed biochemically a stable group. They fermented glucose, maltose, mannite, and dulcite, but not saccharose. Most of them could be distinguished from Salmonella organisms by the late fermentation of lactose or the production of indole. Many resembled the Newcastle bacillus in being late-dulcite fermenters. Serologically 75% of the strains were identical, each containing the A antigen. Some formed a separate group containing the A antigen, andBact. alkalescensantigen and the C antigen of some Group III strains. The A strains are probably identical with those of Dudgeon & Pulvertaft (1927), but their strains were described as being motile. All Group I strains had minor agglutinins in common with the dysentery bacilli, particularly when freshly isolated. Most of Dudgeon's strains were isolated from cases of urinary infection, but in the present investigation almost all were isolated from the discharges of infants with diarrhoea and enteritis. This organism may be regarded as pathogenic or facultatively so, and deserves a name. I suggest it would be appropriate to attach to it the name of Dudgeon, who was the first to call attention to it.Biochemically Group III bacilli resembled Group I strains but differed in fermenting saccharose. Some were motile. The metabolic and biochemical properties examined were stable. Serologically many (40%) possessed the A antigen, but also possessed a type-specific antigen, E. Others (37%) possessed both C and D antigens, usually C but sometimes D was dominant. These strains are related to the dysentery bacilli by the possession of common, minor antigens. A group of serologically heterogeneous strains remained (23%), generally unrelated to the dysentery bacilli.Most Group II bacilli were stable biochemically, but some were not. Many strains of Group IV were unstable. Serologically, Groups II and IV were mostly heterogeneous, although 24% were included in the A, B, C, D, E pattern. Together they formed but a minority of all the paracolon bacilli.Further serological investigation is required to discover new antigens and to link up the paracolon bacilli isolated from various sources.This work was carried out under a whole-time grant from the Medical Research Council of Ireland to whom I am indebted.I wish to record my very best thanks to my director, Prof. R. A. Q. O'Meara, for his continuous interest and invaluable advice at all times and without whose aid this research would not have been possible. My gratitude and thanks are due to my colleague, Dr J. St L. O'Dea, for his unfailing co-operation, particularly in obtaining all the specimens so quickly, in assisting at the post-mortems, and for many other services too numerous to mention.Thanks are also due to the authorities, doctors and nurses of St Ultan's Hospital, Temple Street Hospital, St Kevin's Hospital, Clonskeagh Fever Hospital, Cork Street Hospital, and the Child Welfare Clinics in Dublin, particularly to Dr F. N. Elcock and Dr T. Murphy for their support and co-operation; to the ‘Diarrhoea and Enteritis’ Committee of the Department of Local Government and Public Health for their supervision of the research; and to the staff of the Department of Bacteriology, Trinity College, Dublin, where the research was carried out, for the help and facilities given.I would like to thank all those general practitioners in Dublin who co-operated by the early notification of cases and in other ways. Finally, I wish to record my appreciation to the Statistics Branch, Department of Industry and Commerce, for their interest and kindness in furnishing a valuable report.

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“…agar, both black and white colonies develop. Black colonies possess every characteristic of typical coliforms and when transferred to lactose broth produce acid and 20 per cent or more gas in [18][19][20][21][22][23][24] hours. Moreover, cultures established from black colonies breed true and their origin as a variant of a slow lactose fermenting strain can be determined only by serological methods.9 White colonies in 2-5 days show several small, black, daughter colonies within the white parent colony.…”

Section: Papillae-forming Coliformsmentioning

confidence: 99%