Unusual Radiographic Appearance of Drug-Induced Pharyngeal Angioedema and Differential Considerations

Raman, Siva P.; Lehnert, Bruce E.; Pruthi, Sumit

doi:10.3174/ajnr.a1263

Cited by 9 publications

(6 citation statements)

References 6 publications

(14 reference statements)

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“…Causes of angioedema include allergic and hypersensitivity reactions and, rarely, hereditary disorders such as C1 esterase inhibitor deficiency (31). Angiotensin-converting enzyme (ACE) inhibitors are the most common cause of angioedema, accounting for as many as 35% of cases.…”

Section: Noninfectious Acute Inflammatory Conditions Angioedemamentioning

confidence: 99%

“…ACE inhibitor-mediated angioedema is not a true allergy; instead, ACE inhibitors increase bradykinin activity, which results in transient vasodilatation and extravasation of fluid into the extracellular space. Most patients develop angioedema shortly after beginning ACE-inhibitor therapy; however, the reaction may occur months, or even years, after starting therapy (31,32). Treatment of angioedema involves discontinuing the medication and initiating steroid and antihistamine therapy with supportive care for airway protection.…”

Section: Noninfectious Acute Inflammatory Conditions Angioedemamentioning

confidence: 99%

“…Imaging findings vary, but they most commonly consist of infiltrative, transspacial edema with circumferential mucosal thickening and varying degrees of airway narrowing (Fig 17). However, unilateral, focal, and masslike areas of involvement have been described (31).…”

Section: Noninfectious Acute Inflammatory Conditions Angioedemamentioning

confidence: 99%

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Emergency Imaging Assessment of Acute, Nontraumatic Conditions of the Head and Neck

Capps¹,

Kinsella²,

Gupta³

et al. 2010

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101

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Patients often present to the emergency department with a wide variety of nontraumatic infectious, inflammatory, and neoplastic conditions of the head and neck. Because the use of cervical and neck computed tomography (CT) has become routine in the emergency setting, knowledge of the imaging findings of common acute conditions of the head and neck is essential to ensure an accurate diagnosis of these potentially life-threatening conditions, which include oral cavity infections, tonsillitis and peritonsillar abscess, sialadenitis, parotiditis, diskitis, thrombophlebitis, periorbital and orbital cellulitis, infectious cervical lymphadenopathy, and various neoplasms. Less common conditions that require rapid diagnosis and treatment include epiglottitis, invasive fungal sinusitis, angioedema, and deep neck abscess. Familiarity with these conditions enables the radiologist to make a prompt diagnosis, assess the extent of disease, and evaluate for potential complications. CT is the first-line imaging modality in the emergency setting; however, magnetic resonance imaging plays an important secondary role.

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Section: Noninfectious Acute Inflammatory Conditions Angioedemamentioning

confidence: 99%

Section: Noninfectious Acute Inflammatory Conditions Angioedemamentioning

confidence: 99%

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Emergency Imaging Assessment of Acute, Nontraumatic Conditions of the Head and Neck

Capps¹,

Kinsella²,

Gupta³

et al. 2010

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101

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“…The differential diagnosis of upper airway obstruction includes neoplasms, parapharyngeal abscess, and infection (e.g., tonsillitis, laryngitis, and cellulitis) and these should be excluded by the imaging findings, laboratory data, clinical course, and laryngoscopy [ 14 , 15 ]. Glossomegaly may also be seen in patients with amyloidosis (Fig.…”

Section: Introductionmentioning

confidence: 99%

Radiologic manifestations of angioedema

et al. 2014

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ObjectivesThe purpose of this pictorial review is to present imaging findings of angioedema involving the various organs.ConclusionThe role of imaging for patients with angioedema includes the evaluation of the upper airway for obstruction and the exclusion of other possible aetiologies, such as neoplastic or infectious processes. Glossomegaly is a common finding of head and neck angioedema. Angioedema may involve organ systems beyond the superficial regions and the head and neck including the gastrointestinal and genitourinary tracts. Angioedema of the visceral organs is often accompanied by adjacent fluid, and it is commonly diffuse or concentric but can also be multifocal and asymmetric.Teaching PointsThe evaluation of the upper airway obstruction is important for head and neck angioedema.Glossomegaly with decreased attenuation is common in head and neck angioedema.Angioedema of the visceral organs can be multifocal and asymmetric.Angioedema of the visceral organs is often accompanied by adjacent fluid.It is important to include clinical and laboratory findings for the diagnosis of angioedema.

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“…Една от формите, известна като наследствен ангиоедем (НАЕ) е рядко заболяване (1:50000). То се явява фенотипен израз на наследствен дефицит на С1-естеразния инхибитор, унаследява се по автозомно доминантен тип и нерядко заплашва живота на пациентите [6][7][8][9][10]. В клиничната практика често ангиоедемът е вторичен, а етиологията му е комплексна.…”

Section: въведениеunclassified

Ангионевротичен Оток С Комбинирана Етиология – Клиничен Случай

Дерменджиев¹,

Стойнева-Паскалева²,

Дерменджиев³

et al. 2015

Редки болести и лекарства сираци

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Ангионевротичният оток е често срещано заболяване (15-20% от населението), предизвикващо се от множество етиологични фактори. Клинично се манифестира с едем на дълбоките дермални и субдермални слоеве, понякога съпътстван от сърбеж. Наследственият ангиоедем (НАЕ) е рядко заболяване (1:50000), което е фенотипен израз на наследствен дефицит на С1-естеразния инхибитор. Заболяването се унаследява по автозомно доминантен тип. Активиране на протеазите от системата на комплемента води до образуване на медиатори, които увеличават съдовата пропускливост с клиника на оток по кожата, меките тъкани и вътрешните органи. При първа изява на отока независимо от неговата етиология, винаги трябва да се има предвид и НАЕ. Това налага неговото изключване с утвърдените за целта имунологични изследвания. Не рядко в практиката ангиодемът е вторичен, а етиологията му е комплексна. В тези случаи следва да се имат предвид редица фактори, които едновременно или последователно биха могли да отключат клиничната изява на заболяването. Такъв е представеният от нас случай.

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Unusual Radiographic Appearance of Drug-Induced Pharyngeal Angioedema and Differential Considerations

Cited by 9 publications

References 6 publications

Emergency Imaging Assessment of Acute, Nontraumatic Conditions of the Head and Neck

Emergency Imaging Assessment of Acute, Nontraumatic Conditions of the Head and Neck

Radiologic manifestations of angioedema

Ангионевротичен Оток С Комбинирана Етиология – Клиничен Случай

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