Unusual polymerization of 3-(trimethoxysilyl)-propyldimethyloctadecyl ammonium chloride on PET substrates

El-Ola, S. M. Abo; Kotek, Richard; White, W. Curtis; Reeve, John Allan; Hauser, Peter J.; Kim, Joon Ho

doi:10.1016/j.polymer.2004.02.041

Cited by 45 publications

(25 citation statements)

References 11 publications

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“…Their studies showed that these surfaces were very active in killing S. faecalis even after extensive rinsing with water. Kotek and coworkers applied the same reagent on poly(ethylene terephthalate) fibers reporting that treated fibers had excellent antibacterial effect against E. coli [217].…”

Section: Methods For Making Non-leaching Biocidal Materialsmentioning

confidence: 99%

Infectious disease: Connecting innate immunity to biocidal polymers

Gabriel

Som

Madkour

et al. 2007

Materials Science and Engineering: R: Reports

250

257

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Infectious disease is a critically important global healthcare issue. In the U.S. alone there are 2 million new cases of hospital-acquired infections annually leading to 90,000 deaths and 5 billion dollars of added healthcare costs. Couple these numbers with the appearance of new antibiotic resistant bacterial strains and the increasing occurrences of community-type outbreaks, and clearly this is an important problem. Our review attempts to bridge the research areas of natural host defense peptides (HDPs), a component of the innate immune system, and biocidal cationic polymers. Recently discovered peptidomimetics and other synthetic mimics of HDPs, that can be short oligomers as well as polymeric macromolecules, provide a unique link between these two areas. An emerging class of these mimics are the facially amphiphilic polymers that aim to emulate the physicochemical properties of HDPs but take advantage of the synthetic ease of polymers. These mimics have been designed with antimicrobial activity and, importantly, selectivity that rivals natural HDPs. In addition to providing some perspective on HDPs, selective mimics, and biocidal polymers, focus is given to the arsenal of biophysical techniques available to study their mode of action and interactions with phospholipid membranes. The issue of lipid type is highlighted and the important role of negative curvature lipids is illustrated. Finally, materials applications (for instance, in the development of permanently antibacterial surfaces) are discussed as this is an important part of controlling the spread of infectious disease.

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Section: Methods For Making Non-leaching Biocidal Materialsmentioning

confidence: 99%

Infectious disease: Connecting innate immunity to biocidal polymers

Gabriel

Som

Madkour

et al. 2007

Materials Science and Engineering: R: Reports

250

257

View full text Add to dashboard Cite

show abstract

“…Different papers report on the importance of several parameters influencing antibacterial activity of a surface such as surface topology, surface energy, and the chemical composition of the surface 9–11. In this work, the major aim exists in generating specific functional groups, in particular ammonium groups, mimicking the strong antibacterial effect of these functionalities in solution at the surface of the samples treated by atmospheric plasma technology.…”

Section: Resultsmentioning

confidence: 99%

“…Different studies have emphasized the importance of controlling surface characteristics such as surface energy, roughness, and the presence of specific functional groups in order to increase the antibacterial effectiveness of the layer 9–14. Another type of coatings addresses the utilization of bactericidal metallic agent embedded in polymer matrix 15–20.…”

Section: Introductionmentioning

confidence: 99%

Atmospheric Pressure Plasma Technology: a Straightforward Deposition of Antibacterial Coatings

Sarghini

Paulussen

Terryn

2010

Plasma Processes & Polymers

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Bacterial adhesion and proliferation is a widespread problem following an increasing trend. In this paper, antibacterial coatings were deposited on stainless steel substrates by means of atmospheric pressure plasma technology. Butylamine and 3‐(trimethoxysilyl)‐propyldimethyoctadecylammonium chloride (ODAMO) were used as precursors. The influence of the plasma parameters was investigated by variation of the power input levels and operation under different carrier gases. Characterization of the coating was carried out using contact angle measurement, atomic force microscopy (AFM), field emission scanning electron microscopy (FE‐SEM), and X‐ray photoelectron spectroscopy (XPS). Carrier gas change affected the chemical composition and the surface energy of ODAMO based coating. Moreover, bactericidal activity is decreasing with increase of the plasma power input. Hydrophilic and smooth ODAMO based plasma coating presented the best antibacterial performance. Deposited layers demonstrated up to a log 6 reduction against E. coli after 24 h incubation. Butylamine‐based plasma coatings presented a limited antibacterial effect and the influence of the plasma parameters was not detected.

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“…[40] The wide band in between 3300-3600 cm -1 in the monomer spectrum may also be due to O-H stretching in atmospheric water vapour or residual methanol O-H bonds. [41,42] Figure4:Highresolutionnitrogen1speaksofQASmonomerandpolymersalts(4A)andhighresolutioncarbon 1speaksfrommonomer(4B)andpolymer(4C)…”

Section: Figure3:ftirspectrumoftheqasmonomerandpolymerisedcoatingdepomentioning

confidence: 99%

Protein Adhesion on Atmospheric Plasma Deposited Quaternary Ammonium Salt Coatings

Donegan

Dowling

2013

Plasma Processes & Polymers

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This study investigates protein adhesion on nm thick helium atmospheric plasma deposited quaternary ammonium salt (QAS) coatings. The adhesion of the proteins BSA, IgG and Fg was evaluated on coated and uncoated silicon wafer substrates. This study was carried out in PBS solution, under flow conditions using ellipsometry. The QAS was found to exhibit a low level of solubility in PBS over time (approx. 2 nm / hour). On addition of both the IgG and Fg proteins, it was found that a protective protein layer of 7 and 2 nm respectively was formed, which prevented further dissolution of the QAS. In contrast the 1 nm thick BSA protein layer, which formed on the QAS, was insufficiently thick to prevent the slow dissolution of the salt. It was concluded that the charge and structure of the protein influences its adhesion on the QAS surface. IntroductionA key issue affecting the performance of medical devices in the body is protein adhesion. [1,2] This is because proteins dictate how the cell interacts with the device surface.[3] Although there is a degree of inconsistency within the literature as to the factors influencing protein adsorption on a surface, it is believed that chemical functionality and topography are important factors. [4] Amongst the techniques that have been investigated to alter the surfaces of polymers in order to modify protein adhesion have been micro patterning and monomer polymerisation by free radical solution, emulsion, grafting as well as plasma processes. [5][6][7][8][9] The focus of this study is to investigate how a plasma polymerised quaternary ammonium salt (QAS) coating deposited onto a silicon wafer substrate influences protein adhesion.Worldwide consumption of quaternary ammonium compounds is estimated to be approximately 700,000 tons per annum.[10] Applications of these salts vary from surfactants, corrosion inhibitors and pesticides to personal care products and fabric softeners. [10][11][12] QAS coatings were selected for this study as they have also been reported to exhibit anti-bacterial and anti-fungal properties. [13,14] QAS surfaces have been shown to exhibit a high positive charge density, which exerts a strong electrostatic interaction with negatively charged bacteria. [15] It is reported that after the microbial cell adsorbs onto the coating surface through electrostatic interactions, the alkyl chain of the QAS, if of sufficient length, penetrates the microbial cell wall. This can disrupt the cytoplasmic membrane and release toxins that lead to necrosis. It is suggested that positively charged surfaces can tightly bind the adsorbed microbial cells and prevent their subsequent growth and proliferation, including biofilm formation.[16]There have been relatively few reports on the interaction between QAS surfaces and proteins.There have also been some inconsistencies between the adhesion results obtained by different authors. [17][18][19] It has been shown that quaternary ammonium based polymer coatings provide effective resistance against the non-specific adsorption of proteins ...

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Unusual polymerization of 3-(trimethoxysilyl)-propyldimethyloctadecyl ammonium chloride on PET substrates

Cited by 45 publications

References 11 publications

Infectious disease: Connecting innate immunity to biocidal polymers

Infectious disease: Connecting innate immunity to biocidal polymers

Atmospheric Pressure Plasma Technology: a Straightforward Deposition of Antibacterial Coatings

Protein Adhesion on Atmospheric Plasma Deposited Quaternary Ammonium Salt Coatings

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