Unusual perianesthetic malignant hyperthermia in a dog

Abstract

Dogs affected by genetic muscle disorders should be considered at risk for perianesthetic malignant hyperthermia, even in the absence of an RYR1 gene mutation.

Unusual hyperthermia related to general anaesthesia in an Anatolian shepherd dog

“…Diazepam is an effective muscle relaxant and anticonvulsant (Lemke 2007). The vasodilatation caused by the drug (Adami et al 2012) also leads to a lowering of body temperature. The drug provided sufficient muscle relaxation following administration.…”

“…Th is increase may occur 10-70 minutes after halothane or isofl urane administration in patients pre-medicated prior to general anaesthesia (Nelson 1991;Chohan and Greene 2011;Adami et al 2012). Due to their protective eff ects against MH, the fi ndings of MH may be delayed (Gronert and Milde 1981;O'Brien et al 1983).…”

“…Since dantrolene (Adami et al 2012) was unavailable in the hospital, alternative treatment options were utilised to keep the patient alive. Diazepam is an effective muscle relaxant and anticonvulsant (Lemke 2007).…”

“…However, in the absence of dantrolene, alternative drugs, effective in lowering body temperature and eliciting muscle relaxation, may be used (Lemke 2007;Adami et al 2012).…”

Skin and Musculoskeletal Diseases

“…Total intravenous anesthesia is considered if anesthesia cannot be terminated but may not prevent a MH-like syndrome to occur. 52 Effective sedation and analgesia are important in order to minimize perioperative stress and pain, respectively, as these are considered to be triggering factors. An opioid (morphine [0.5-1 mg kg −1 ] or methadone [0.5 mg kg −1 ] IM) can be given with midazolam (0.2 mg kg −1 IM), ACE (0.02-0.05 mg kg −1 IM), or dexmedetomidine (3-5 μg kg −1 IM).…”