Unusual Color Reaction in Glycosuria Testing During Cephalothin Administration

Kostis, John B.

doi:10.1001/jama.1966.03100220097043

Cited by 5 publications

(2 citation statements)

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“…Cephalosporins. Most cephalosporin and cephalosporin-like antibiotics currently available in the United States have been studied (Table 1; 32,[34][35][36][37][38][39][40]. Several investigators have demonstrated that these cephalosporins consistently produce false-positive Clinitest results (32,(34)(35)(36).…”

Section: Group a Drugsmentioning

confidence: 99%

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Review of Drug Interference With Urine Glucose Tests

Rotblatt¹,

Koda-Kimble²

1987

Diabetes Care

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Many drugs have been reported to interfere with copper-reduction or glucose oxidase tests used to measure urine glucose. However, only a few drugs or drug classes have been well documented to clinically interfere with these tests. The interfering drugs include ascorbic acid, beta-lactam antibiotics (e.g., cephalosporins and penicillins), levodopa, and salicylates. Several other drugs may also interfere with certain urine glucose tests, but the interactions are poorly documented. These drugs include chloral hydrate, hyaluronidase, nalidixic acid, nitrofurantoin, p-aminosalicylic acid, phenazopyridine, probenecid, and X-ray contrast media. Drugs or their metabolites that are strong reducing substances produce false-positive results by the copper-reduction method and false-negative results by the glucose oxidase method. The beta-lactam antibiotics interfere with copper-reduction tests by producing copper compounds of various colors that confuse interpretation of test results. Tables are provided that summarize the drug interferences discussed.

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Section: Group a Drugsmentioning

confidence: 99%

“…Colors that have been reported as brown, black, or green are either uninterpretable or mistakenly interpreted as the greenbrown color that occurs after a pass-through phenomenon (34,37,39,40). Only moxalactam does not interfere with the Clinitest reaction (32).…”

Section: Group a Drugsmentioning

confidence: 99%