Unusual Clinical Presentation of Regression in a Congenital Melanocytic Nevus

Arpaia, Nicola; Cassano, Nicoletta; Filotico, Raffaele; Laricchia, Francesco; Veña, Gino Antonio

doi:10.1111/j.1524-4725.2005.31117

Cited by 5 publications

(3 citation statements)

References 35 publications

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“… 4 Halo phenomenon may also develop around Mongolian spot, café au lait macules, neurofibroma, basal cell carcinoma, seborrheic keratosis, histiocytoma, and flat warts. 8 The clinical manifestation of halo phenomenon is characterized by progressive lightening of the color, disappearance of central nevus afterwards, and persistence of hypopigmentation. 5 …”

Section: Introductionmentioning

confidence: 99%

Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon

Lee

Chung

Hong

et al. 2015

The American Journal of Dermatopathology

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Abstract:Congenital melanocytic nevus (CMN) is a neural crest-derived hamartoma, which appear at or soon after birth. CMN has a dynamic course and may show variable changes over time, including spontaneous involution. Spontaneous involution of CMN is a rare phenomenon and is often reported in association with halo phenomenon or vitiligo. The mechanism of halo phenomenon is yet to be investigated but is suggested to be a destruction of melanocytes by immune responses of cytotoxic T cells or IgM autoantibodies. Here, the authors report an interesting case of spontaneously regressed medium-sized CMN with halo phenomenon and without vitiligo, which provides evidence that cytotoxic T cells account for the halo formation and pigmentary regression of CMN.

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Section: Introductionmentioning

confidence: 99%

Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon

Lee

Chung

Hong

et al. 2015

The American Journal of Dermatopathology

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“…Targeting keratinocyte cytokines might provide hope for a drug therapy by which giant nevi could be controlled, or even reversed, since they can spontaneously regress (Arpaia et al, 2005;Cusak et al, 2009 . At P10 small nests of melanocytic cells (nevi) appear within the superficial dermis around hair follicles (Chai et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…One would hope to have a drug therapy by which giant nevi could be controlled, or even reversed, since they can spontaneously regress (Arpaia et al, 2005;Cusak et al, 2009). Surgical excision is the gold standard for treatment of most cutaneous tumours.…”

Section: Nras-cdk4-cdonmentioning

confidence: 99%

The Role of Microenvironment in Development of Skin Cancer and Metastasis

Chitsazan¹

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The overarching aim of this thesis is to study the mechanisms by which giant congenital nevi form and to study if such mechanisms are targetable. Virtually nothing is known about genes conferring susceptibility to the development of giant congenital nevi, largely untreatable lesions which increase the risk of patients for development of neurocutaneous melanocytoma and malignant melanoma. To discover such genes, we utilized a nevusprone transgenic mouse model together with the Collaborative Cross (CC), a genetic resource for discovery of genes for complex diseases. It not only allows gene discovery, but also a systems genetics approach that enabled us to determine how the gene functions in vivo to modify the nevogenesis.We also show that the identity of somatic oncogenic mutation (e.g. in NRAS) does not always define the histopathological subtype of nevus, as is generally thought. In sum, we have performed an unbiased genetic screen and discovered a novel gene (Cdon), a dependence receptor of sonic hedgehog (Shh) as the modifier gene for nevus exacerbation. We then used three different mouse models to validate it as the causal gene and determine its mechanism of action. We also show that Shh pathway components are active in the epidermis adjacent to human congenital nevi (Chapter 2 and 3). In summary this is the first time a gene has been successfully mapped and functionally validated using CC. In Chapter 4 we discuss the result from an unbiased genetic screen to map the modifier gene for development of sub-cutaneous (hypodermis) metastasis using 45 CC strains. Gja1 which encodes a gap junction subunit connexion 43 (Cx43) is the best candidate. Our gene expression and protein expression studies suggest that Gja1 could be a strong candidate for further study of sub-cutaneous metastasis.In Chapter 5 we went on to study the gene expression of normal skin, melanocytoma and malignant melanoma samples from our NRAS-Cdk4 mouse model to study the transformation and progression of melanocytic lesions. Dusp6 a negative regulator of MAPK pathway was highly upregulated with transformation and progression. Our protein expression study validated this result on murine and human nevi versus malignant melanoma samples.3

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Hypomelanotic Conditions of the Newborn and Infant

Ruiz-Maldonado

2007

Dermatologic Clinics

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Unusual Clinical Presentation of Regression in a Congenital Melanocytic Nevus

Abstract: In our case, the presence of a regression area in the surrounding skin and the association with multiple halo nevi suggest a similarity with halo phenomenon, despite the atypical "halo," which was discontinuous and eccentric.

Cited by 5 publications

References 35 publications

Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon

Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon

The Role of Microenvironment in Development of Skin Cancer and Metastasis

Hypomelanotic Conditions of the Newborn and Infant

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