Hypomelanotic Conditions of the Newborn and Infant

Ruiz-Maldonado, Ramon

doi:10.1016/j.det.2007.05.005

Cited by 26 publications

(16 citation statements)

References 22 publications

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“…If the treatment (a lifelong low phenylalanine diet) is neglected, mental retardation, epilepsy and extra-pyramidal signs can arise. [11]…”

Section: Diffuse Hypomelanosesmentioning

confidence: 99%

“…The primary lesions (small, flat, skin-colored to pink papules) can disappear spontaneously after several months or years, often leaving a linear macular hypopigmentation (post-inflammatory). [11] Other skin infections/inflammations like impetigo and chickenpox, tuberculoid leprosy, insect bites, atopic dermatitis, physical agents such as burns or minor injuries or pytiriasis lichenoides chronica, hypopigmented mycosis fungoides and progressive macular hypomelanosis can also cause secondary or post-inflammatory hypopigmentation. [28] The latter four disorders usually manifest at later age, but can be present during puberty or adolescence.…”

Section: Localized Hypomelanosesmentioning

confidence: 99%

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Hypomelanoses in children

Geel

Speeckaert

Chevolet

et al. 2013

J Cutan Aesthet Surg

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Hypomelanosis of the skin is a frequently encountered problem in childhood, being totally innocent or representing the first sign of a multisystem disorder. Medical history, clinical examination, Wood’s light investigation, histological analysis of the skin and a multidisciplinary consultation can contribute to a correct and early diagnosis of the different types of hypopigmentations. In the present paper, we present a systematic clinical approach to the differential diagnosis of those skin disorders.

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“…If the treatment (a lifelong low phenylalanine diet) is neglected, mental retardation, epilepsy and extra-pyramidal signs can arise. [11]…”

Section: Diffuse Hypomelanosesmentioning

confidence: 99%

Section: Localized Hypomelanosesmentioning

confidence: 99%

Hypomelanoses in children

Geel

Speeckaert

Chevolet

et al. 2013

J Cutan Aesthet Surg

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“…Although it has a worldwide distribution, it is frequently seen in tropical areas of the world; therefore, it is more evident in individuals with darker complexion, although it is present in all skin types [1–5]. There are two types of PA, the endemic, affecting infants and children of low socioeconomic conditions in developing countries, and atopic-dermatitis-related PA which is associated with postinflammatory hypopigmentation [6]. This entity has received many synonyms (i.e., chronic impetigo, erythema streptogenes).…”

Section: Introductionmentioning

confidence: 99%

Double-Blind, Placebo-Controlled, Randomized Study Comparing 0.0003%Calcitriol with 0.1%Tacrolimus Ointments for the Treatment of Endemic Pityriasis Alba

Moreno-Cruz

Torres-Álvarez

Hernández-Blanco

et al. 2012

Dermatology Research and Practice

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Background. Pityriasis alba (PA) is a frequent cause of consultation in tropical areas due to its chronic course, frequent relapses, and notorious hypopigmented lesions in pediatric dark skin populations. Currently, no treatment is widely accepted. Objective. To assess the efficacy of 0.0003% calcitriol and 0.1% tacrolimus ointments compared with placebo in the treatment of endemic PA. Methods. Twenty-eight children aged 3–17 years with 56 symmetrical lesions and phototype IV-V, were randomly assigned to receive the treatments on target lesions on the face. Improvement was evaluated at baseline and 8 weeks later clinically and by digital quantification of the affected area, colorimetry, and transepidermal water loss (TEWL). Results. Tacrolimus and calcitriol ointments induced a mean improvement of 68%, compared to 44% of placebo. We found an elevated TEWL in PA lesions. In the treated plaques, the reduction of the affected area was associated with improvement of pigmentation and TEWL. Conclusions. Calcitriol and tacrolimus induced similar repigmentation in endemic PA lesions. Melanogenic, anti-inflammatory, and barrier defect restoration properties of these drugs may explain these findings.

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“…Melanositlerin fonksiyonlarının bozulması veya ortadan kalkması hipopigmentasyon veya depigmentasyona yol açar 1,2 . Çocuklardaki hipopigmentasyon bozuklukları çeşitli konjenital ve edinsel hastalıklara bağlı olabilir.…”

Section: Gi Riflunclassified

“…Proteinli gıdalarda bulunan fenilalaninin, karaciğerde metabolize edilememesi sonucu fenilalanin ve metabolitlerinin kan ve dokularda birikmesi sonucu klinik bulgular görülür. Deri, saç ve gözlerde pigmentasyon azlığı, erken diyet uygulanmazsa mental retardasyonla karakterizedir 2,13 .…”

Section: Fenilketonüriunclassified

Hypopigmented Disorders Except Vitiligo

Doğramacı¹

2011

Turkderm

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ÖzetÇocuklardaki hipopigmentasyon bozuklukları çeşitli konjenital ve edinsel hastalıklara bağlı olarak ortaya çıkabilir. Bu hipopigmente lezyonlar yaygınlıklarına göre generalize ve lokalize olmak üzere iki gruba ayrılabilir. Klinik bulgulardaki farklılıklar, pigment kaybının derecesi, ilişkili morfolojik bulgular hastalıkların ayrımında kullanılan önemli göstergelerdir. Bu derlemede çocuklarda hipopigmentasyon ile seyreden vitiligo dışındaki deri hastalıkları irdelenmektedir. Sum maryHypopigmentation disorders in children can be due to a wide variety of congenital and acquired diseases. They can be classified on the basis of lesion extent, and can generally be divided into disorders with localized or generalized lesions. Clinical findings, comprising the degree of pigment loss and associated morphological findings are used to further distinguish the disorders. This review deals with skin diseases with hypopigmentation other than vitiligo as the main clinical presenting feature in children. (

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Hypomelanotic Conditions of the Newborn and Infant

Cited by 26 publications

References 22 publications

Hypomelanoses in children

Hypomelanoses in children

Double-Blind, Placebo-Controlled, Randomized Study Comparing 0.0003%Calcitriol with 0.1%Tacrolimus Ointments for the Treatment of Endemic Pityriasis Alba

Hypopigmented Disorders Except Vitiligo

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