Unusual Case of Necrotizing Fasciitis Caused by Vibrio cholerae O137

Ottaviani, Donatella; Leoni, Francesca; Rocchegiani, Elena; Canonico, Cristina; Masini, Laura; Pianetti, A.; Parlani, Chiara; Luzzi, Ida; Caola, Iole; Paternoster, C.; Carraturo, Antonio

doi:10.1128/jcm.02257-10

Cited by 16 publications

(10 citation statements)

References 12 publications

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“…Though the isolates lacked virulence genes encoding for CT, Stn, Chx and structural genes of T3SS, the potential virulence genes such as hlyA, mshA , and rtxA were detected in all the isolates. Association of these genes in V. cholerae non-O1/non-O139 isolates has been reported in many findings ( Ottaviani et al, 2011 ; Dutta et al, 2013 ; Khan et al, 2013 ; Rajpara et al, 2013 ). Since V. cholerae non-O1/non-O139 is endemic in many regions, there should be a standby schema in place for routine screening this organism from septicemia/UTI cases.…”

Section: Discussionmentioning

confidence: 87%

Extraintestinal Infections Caused by Non-toxigenic Vibrio cholerae non-O1/non-O139

et al. 2016

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Vibrio cholerae is an aerobic, sucrose fermentative Gram-negative bacterium that generally prevails in the environment. Pathogenic V. cholerae is well-known as causative agent of acute diarrhea. Apart from enteric infections, V. cholerae may also cause other diseases. However, their role in causing extraintestinal infections is not fully known as it needs proper identification and evaluation. Four cases of extraintestinal infections due to V. cholerae non-O1/non-O139 have been investigated. The isolates were screened for phenotypic and genetic characteristics with reference to their major virulence genes. Serologically distinct isolates harbored rtx, msh, and hly but lacked enteric toxin encoding genes that are generally present in toxigenic V. cholerae. Timely detection of this organism can prevent fatalities in hospital settings. The underlying virulence potential of V. cholerae needs appropriate testing and intervention.

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Section: Discussionmentioning

confidence: 87%

Extraintestinal Infections Caused by Non-toxigenic Vibrio cholerae non-O1/non-O139

et al. 2016

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“…In Europe, the increase of the frequency of infections due to non-O1/non-O139 V. cholerae in connection with the aquatic environment is reported by numerous authors (Dalsgaard et al, 2000 ; Ninin et al, 2000 ; Andersson and Ekdahl, 2006 ; Ottaviani et al, 2011 ; Hirk et al, 2016 ). This increase may be partially related to global warming.…”

Section: Introductionmentioning

confidence: 88%

Antimicrobial Susceptibility among Urban Wastewater and Wild Shellfish Isolates of Non-O1/Non-O139 Vibrio cholerae from La Rance Estuary (Brittany, France)

et al. 2017

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The early 2000s marked the end of the Golden age of the antibiotics and the beginning of the awareness on the potential threat to human health due to the dissemination of antimicrobial resistance. As a base-line study, we investigated the antimicrobial susceptibility of 99 strains of non-O1/non-O139 Vibrio cholerae isolated from wastewater and shellfish in 2000/2001 within La Rance estuary (Brittany, France). All isolates were susceptible to amoxicillin-clavulanic acid, cefotaxime, imipenem, chloramphenicol, nalidixic acid, ciprofloxacin, norfloxacin, amikacin, gentamicin, tetracycline, doxycycline, trimethoprim-sulfamethoxazole, and erythromycin. The only resistances were to streptomycin, sulfonamides and ampicillin: 54.6% of the isolates had acquired resistance to at least one antimicrobial agent among them and only six isolates from cockles were multidrug resistant. On the basis of the distribution of a limited selection of resistance associated genes, our study shows that V. cholerae can constitute an environmental reservoir for these genes. However, none of our isolates harbored integron. This result casts doubt on the capacity of non-O1/non-O139 V. cholerae to acquire resistance-associated genes in such context, and on its potential role of indicator of the dissemination of antimicrobial resistance in the aquatic environment.

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“…Necrotizing fasciitis due to non-O1/non-O139 V. cholerae has previously been reported in the scientific literature. In Europe, one isolated case of necrotizing fasciitis caused by non-O1/non O-139 V. cholerae (and associated with water exposure) was reported Italy (Mediterranean sea) [ 12 ]. In contrast to our Austrian cases, all those infections were associated with saline waters, as were singular reports of V. cholerae non-O1/non O-139 necrotizing fasciitis from the United States [ 13 ] and Taiwan [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Necrotizing fasciitis due to Vibrio cholerae non-O1/non-O139 after exposure to Austrian bathing sites

Hirk

Huhulescu

Allerberger

et al. 2016

Wien Klin Wochenschr

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SummaryWe report on two cases of necrotizing fasciitis of the lower leg due to nontoxigenic Vibrio cholerae (V. cholerae). A 73-year-old woman (case 1) and an 80-year-old man (case 2) were hospitalized with symptoms of necrotizing fasciitis on July 18 and August 15, 2015, respectively. In both cases, symptoms started the day after swimming in local ponds. Swabs gained intraoperatively and a blood culture from the male patient, yielded V. cholerae non-O1/non-O139, negative for cholera toxin gene ctx and positive for hemolysin genes hlyA and hlyB. Water samples taken from pond A on August 17, 2015 (32 days after exposure of case 1) and from pond B on August 20, 2015 (7 days after exposure of case 2) yielded non-O1/non-O139 V. cholerae in most-probable numbers of > 11,000 per 100 ml each. The occurrence of two cases of necrotizing fasciitis within a 1 month period related to two Austrian non-saline bathing waters, previously not known to harbor V. cholerae, is probably linked to the prevailing extreme weather conditions (heat wave, drought) this summer in Austria. While case 1 was discharged in good clinical condition after 73 days, case 2 died after four months of hospitalization. Public health authorities are challenged to assess the effects of long-term climate change on pathogen growth and survival in continental bodies of fresh water.

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Unusual Case of Necrotizing Fasciitis Caused by Vibrio cholerae O137

Cited by 16 publications

References 12 publications

Extraintestinal Infections Caused by Non-toxigenic Vibrio cholerae non-O1/non-O139

Extraintestinal Infections Caused by Non-toxigenic Vibrio cholerae non-O1/non-O139

Antimicrobial Susceptibility among Urban Wastewater and Wild Shellfish Isolates of Non-O1/Non-O139 Vibrio cholerae from La Rance Estuary (Brittany, France)

Necrotizing fasciitis due to Vibrio cholerae non-O1/non-O139 after exposure to Austrian bathing sites

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