Unusual case of melanocytoma

Al-Hinai, Ahmed; Edelstein, Chaim; Burnier, Miguel N.

doi:10.1016/s0008-4182(04)80020-6

Cited by 14 publications

(12 citation statements)

References 6 publications

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“…Histopathologically, the tumor is composed of either Type I or Type II. Type I cells are typically large, polyhedral with abundant cytoplasm, giant melanosomes and small round nuclei as in our case 11 . Type II cells are more elongated with smaller melanin pigments.…”

Section: Discussionmentioning

confidence: 54%

Acute subconjunctival pigmentation with an underlying ciliary body mass: An unusual case presentation

Alkatan

Fathaddin

Mahmood

et al. 2019

Saudi Journal of Ophthalmology

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Intraocular melanocytoma is a rare slowly growing benign tumor that may occur anywhere along the uveal tract including the ciliary body but is more commonly found near the optic disc. It is darkly pigmented and may exhibit fast growth and possibly malignant transformation. Ciliary body (CB) melanocytoma is rare and often misdiagnosed as a melanoma. We are reporting a case of CB melanocytoma in a 74-year old lady with unusual initial presentation of an acute onset of subconjunctival pigmentation and extra-scleral extension of the melanocytoma with coarse melanin granules. The diagnosis of melanocytoma was confirmed by histopathological examination of the prolapsed tissue and by ultrastructural studies. Literature review of similar cases is also summarized.

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Section: Discussionmentioning

confidence: 54%

Acute subconjunctival pigmentation with an underlying ciliary body mass: An unusual case presentation

Alkatan

Fathaddin

Mahmood

et al. 2019

Saudi Journal of Ophthalmology

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“…In the present paper, a patient presenting with unilateral glaucoma associated with hyperchromic heterochromia was successfully treated with an Ahmed valve implant, rather than enucleation, demonstrating the importance of histopathologic analysis in determining diagnosis and treatment 1. Nevertheless, we should consider that a small incisional biopsy is not always representative of the whole lesion as cytological features may differ across the tumour.…”

Section: Discussionmentioning

confidence: 80%

“…Mitotic figures are usually absent. Although histologically benign, this tumour may spontaneously undergo necrosis and consequently pigment dispersion 1. Macrophages that ingest pigment particles released from the necrotic tumour may cause secondary open-angle glaucoma by mechanically obstructing the trabecular meshwork.…”

Section: Answersmentioning

confidence: 99%

Management of glaucoma in an eye with diffuse iris melanocytoma

Alves¹,

Fernandes

Menezes³

et al. 2010

British Journal of Ophthalmology

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A 68-year-old Caucasian male was referred for evaluation and follow-up of unilateral glaucoma resistant to control with topical medication. Corrected visual acuity was 20/20 in the right and 20/25 in the left eye. Biomicroscopy was normal and the intraocular pressure (IOP) was 14 mm Hg in the right eye. In the left eye, ciliary injection, a diffuse iris hyperchromia (figure 1A), discrete corneal oedema with the presence of sparse pigment deposits on the endothelium (figure 1B), and mild anterior chamber reaction (+/4+) were observed. The angle was obstructed inferiorly by the pigment deposition, while the parts of the angle that were visible showed increased pigmentation of the trabecular meshwork during gonioscopy. The iris surface was smooth and the crypts were absent. The pupil was round but fixed in medium mydriasis with a posterior synechia seen at 1 h. In addition, the lens had nuclear sclerosis and the IOP was measured at 58 mm Hg. Funduscopy disclosed increased cup-todisc ratio in the left (0.7) compared with the right eye (0.4), but was otherwise unremarkable.The patient's relevant medical history included controlled hypertension and a basal cell carcinoma in the left arm Education group.bmj.com on June 29, 2015 -Published by

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“…The growth of benign lesions confirmed by post-enucleation histopathology study, has been documented in 10-15% of cases [9][10][11][12][13]16,17,[21][22][23][24]30,31,33,37,38 , after several years of follow-up (approximately 5 to 20 years) 4 .…”

Section: Clinical Presentationmentioning

confidence: 92%

“…A similar finding was observed in a study in Korean population with a mean age at diagnosis of 46 years. 15 Melanocytoma is part of the 0.55% of pigmented intraocular tumors, and its most frequent intraocular location is the optic nerve 16 . There are reports with an increased incidence in female (62%) than in male (38%) 14,17 , data that correspond to the Korean (63%) 15 and European (62%) populations 7 .…”

Section: Epidemiologymentioning

confidence: 99%