Unusual Association of Adrenal Angiosarcoma and Cushing’s Disease

“…The youngest patient diagnosed with PAA was a 34-year old that had overt Cushing's syndrome due to ACTH-secreting pituitary adenoma and PAA described by Invitti et al in 2001. Some patients can have symptoms similar to paraneoplastic syndrome as was described by Bosco et al (1994).…”

Section: Review Discussion and Conclusionmentioning

confidence: 91%

“…According to Rosen et al (1988), MeisKindblom and Kindblom (1998) and Deyrup et al (2009) (Kareti et al, 1988;Livatidou et al, 1991;Bosco et al, 1991;Wenig et al, 1994;Otal et al, 1999;Ben Izhak et al, 1999;Krüger et al, 2001;Croitoru et al, 2001;Invitti et al, 2001;Pasqual et al, 2002;Lepoutre-Lussey et al, 2012;Derlin et al, 2012).…”

Section: Review Discussion and Conclusionmentioning

confidence: 99%

Adrenal Gland Hemangiosarcoma in a Patient with Chronic Myeloid Leukaemia

Bacalja¹,

Ulamec²,

Rako³

et al. 2013

IJCRM

View full text Add to dashboard Cite

Hemangiosarcomas are rare tumours, predominantly affecting adult and elderly patients. Most frequently they involve the skin, although they can occur in visceral organs and other tissues. Hemangiosarcomas pursue an aggressive clinical course with high mortality rates. Primary adrenal hemangiosarcoma is extremely rare. We report a case of a 64-year-old male patient. He underwent ultrasound and computed tomography scan because of pain in his left lumbar area present over the previous 2 months. Tumor mass of the adrenal gland was found and he underwent left adrenalectomy. Macroscopically, cystic tumor that measured up to 9 cm in diameter was found. Histological diagnosis was hemangiosarcoma. The patient was being treated for chronic myeloid leukaemia for 7 years. During the time the adrenal tumor was diagnosed, he had been in remission. He died one and a half months after tumor resection because of profound bleeding in postoperative area. To our knowledge, this is the first case of a primary adrenal gland hemangiosarcoma in a patient treated for chronic myeloid leukaemia.

show abstract

“…Association between a primary adrenal angiosarcoma and an adrenocortical adenoma has never been reported before. PAA was diagnosed in a patient presenting with Cushing's syndrome but in this case, hypercortisolism was due to an ACTH-producing pituitary adenoma (11). The relationship, if any, between the two tumors is unclear.…”

Section: Discussionmentioning

confidence: 92%

Primary adrenal angiosarcoma and functioning adrenocortical adenoma: an exceptional combined tumor

Lepoutre-Lussey

Rousseau²,

Ghuzlan³

et al. 2012

European Journal of Endocrinology

View full text Add to dashboard Cite

Context: Primary adrenal angiosarcoma is an extremely rare neoplasm, as are combined tumors within a given adrenal lesion. Clinical presentation and intervention: A 35-year-old man presented with hypokalemic hypertension leading to the discovery of a 6 cm diameter malignant-appearing right adrenal tumor. The lesion displayed marked 18 F-fluorodeoxyglucose uptake on positron emission tomography scanning. Endocrine investigations revealed secretion of both cortisol and aldosterone by the neoplasm. The entire right adrenal gland along with the periadrenal fat tissue was removed during laparoscopic surgery. Results: Histological examination revealed two intermingled tumor cell proliferations, namely an angiosarcoma and an adrenocortical adenoma. An extensive post-operative search revealed no other primary tumor site, nor metastases. The lesion was then considered to be a primary adrenal angiosarcoma combined with a secreting adrenocortical adenoma. The patient received four cycles of chemotherapy (adriamycin/ifosfamide). At 2-year follow-up, he is alive and well, with no sign of relapse. Conclusion: To the best of our knowledge, this is the first case of an adrenal neoplasm combining a primary angiosarcoma and a functioning adrenocortical adenoma.

show abstract

Unusual Association of Adrenal Angiosarcoma and Cushing’s Disease

Cited by 14 publications

References 26 publications

Recurrence of Cushing’s disease after primary transsphenoidal surgery in a university hospital in Korea

Recurrence of Cushing’s disease after primary transsphenoidal surgery in a university hospital in Korea

Adrenal Gland Hemangiosarcoma in a Patient with Chronic Myeloid Leukaemia

Primary adrenal angiosarcoma and functioning adrenocortical adenoma: an exceptional combined tumor

Contact Info

Product

Resources

About