Unusual Annular Erythema Associated with Myelodysplastic Syndrome

Yamamoto, Toshiyuki; Soejima, Kenzo; Yokozeki, Hiroo; Koyano, Takayuki; Katayama, Isao; Nishioka, K.

doi:10.1159/000051592

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…H-SS was previously shown to occur at the onset or preceding MDS in most cases. 10 , 39 , 40 In our study, the hematological disease was mostly diagnosed before the diagnosis of H-SS. However, 3 patients presented cutaneous lesions of H-SS before the diagnosis of hematological malignancy, MDS in all these cases, within a 6-month interval.…”

Section: Discussionmentioning

confidence: 82%

Histiocytoid Sweet Syndrome Is More Frequently Associated With Myelodysplastic Syndromes Than the Classical Neutrophilic Variant

et al. 2016

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Histiocytoid Sweet syndrome (H-SS) is a histological variant of Sweet syndrome (SS) differing from classical neutrophilic SS (N-SS) by a dermal infiltrate mainly composed of lymphocytes and histiocytoid myeloperoxidase-positive cells. We aimed to report a large series of H-SS and compare the frequency and type of hematological malignancies associated to H-SS and N-SS. We included 62 patients with a coding histopathologic diagnosis of SS prospectively registered between 2005 and 2014 in the database of our Department of Pathology. Overall, 22 (35.5%) and 40 (64.5%) patients had a histological diagnosis of H-SS and N-SS, respectively. Median age, sex ratio, and cutaneous lesions were similar in the 2 groups. The frequency of extra-cutaneous manifestations was similar (50% vs 37.5%, P = 0.42). Recurrent forms were significantly more frequent in H-SS than in N-SS patients (21% vs 2.5%, P = 0.01). A hematological malignancy was diagnosed in 22 patients, 12 (55.5%) with H-SS and 10 (25%) with N-SS (P = .019). Hematological malignancy was of myeloid origin in 8/22 (36.3%) H-SS and 5/40 (12.5%) N-SS patients (P = .02), and of lymphoid origin without myeloid component in 4/22 (18.1%) H-SS and 4/40 (10%) N-SS patients (P = .35), respectively. One N-SS patient had a hematological malignancy of mixed (myeloid and lymphoid) phenotype. A myelodysplastic syndrome (MDS) was diagnosed in 7/22 (31.8%) H-SS and 1/40 (2.5%) N-SS patients (P < .001). Hematological disease was diagnosed before (in 8 H-SS and 3 N-SS patients) or at the time of the occurrence of the cutaneous lesions (in 1 H-SS and 7 N-SS patients). However, in 3 H-SS patients, all with MDS, cutaneous lesions preceded the hematological disease by ≤6 months. In conclusion, H-SS was associated with MDS in one third of patients but also with lymphoid malignancies, and cutaneous lesions could precede the hematological diagnosis in patients with MDS. A complete hematological assessment is mandatory at diagnosis, and monitoring blood cell counts should be recommended for at least 6 months after the diagnosis of H-SS.

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Section: Discussionmentioning

confidence: 82%

Histiocytoid Sweet Syndrome Is More Frequently Associated With Myelodysplastic Syndromes Than the Classical Neutrophilic Variant

et al. 2016

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“…13,18,19 Myelodysplastic syndrome occurred at the onset of cutaneous disease in 2 patients or followed it 3 years later in 1. In a series of 37 patients with Sweet syndrome who had undergone sequential biopsies, the initial lymphocytic stage was followed by neutrophilic and then histiocytic infiltrates.…”

Section: Commentmentioning

confidence: 99%

Chronic Recurrent Lymphocytic Sweet Syndrome as a Predictive Marker of Myelodysplasia

Vignon-Pennamen¹,

Juillard²,

Rybojad³

et al. 2006

Arch Dermatol

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“…18 There is a report of annular erythema in a patient with myelodysplasia clinically resembling SS but with a mononuclearpredominant dermal infiltrate. 19 One of us (personal observation, J.C.M., 2003) has observed interstitial granulomatous dermatitis with small mononuclear cells presumed to be monocytes or small histiocytes in a mixed infiltrate containing many neutrophils and eosinophils. The true origin of these cells is a question begging to be answered with a battery of immunohistochemical, cytochemical, and enzymatic stains.…”

Section: See Also Pages 834 881 and 887mentioning

confidence: 99%