Unusual and rare case of generalised lymphadenopathy: Kimura’s disease

Abstract

We report a case of Kimura’s disease in a 65-year-old woman who presented with generalised itching, abdominal pain, facial puffiness, difficulty in swallowing and loss of appetite. She was found to have generalised lymphadenopathy and a fine-needle aspiration cytology initially done revealed ‘reactive lymphadenitis’ which was inconclusive. PET-CT done showed features suggestive of lymphoma. Hence, lymph node biopsy was done for confirmation and incidentally after immunohistochemistry staining it turned out to be Kimura’s disease. High-dose steroid therapy was started and patient showed dramatic clinical and symptomatic improvement. Kimura’s disease almost always presents as cervical lymphadenopathy and usually never causes compressive symptoms. Our patient presented with compressive symptoms and generalised lymphadenopathy which is a rarity.

Coexisting Nodular Sclerosis Hodgkin Lymphoma and Kimura’s Disease: A Case Report and Literature Review

“…However, some exceptions may exist. One patient with KD-associated generalized lymphadenopathy was reported to suffer from compressive symptoms causing dysphagia [14], mimicking malignant lymphomas. Previous studies have attempted to distinguish the two processes via imaging studies.…”

Comparison between Kimura’s disease and angiolymphoid hyperplasia with eosinophilia: case reports and literature review

“…8 Kimura's disease is an inflammatory disorder of unknown aetiology that most commonly presents as painless lymphadenopathy or subcutaneous masses in the head and neck region. 10 Patients are typically males of Asian descent in their 30s and the sex ratio is 4-7:1. 11 In the clinical setting, one or multiple painless deep hypodermic subcutaneous nodules are usually observed, mostly in the head and neck and mainly in the subcutaneous tissues, salivary glands or cervical lymph nodes.…”