Untersuchungen über reversible Linsentrübungen bei Ratten und Mäusen nach kombinierter Applikation von Phenelzin und Serotonin

Tilgner, S.; Kusch, T

doi:10.1159/000305906

Cited by 6 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The influence of 5-HT on the rat's lens has been described by Tilgner & Kusch [31]. Cataracts were found when a subcutaneous injection of 5-HT was combined with a previous injection of phenelzine (a MAO-inhibitor).…”

Section: Discussionmentioning

confidence: 87%

Serotonin (5-HT) and the rat's eye

1992

View full text Add to dashboard Cite

Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic amine which has a multitude of more or less clearly established effects on peripheral vessels. It influences blood viscosity, platelet aggregation, and vasoconstruction and -dilatation, it enhances capillary permeability, it is the precursor of melatonin (a hormone with diurnal production in the eye). Because of these actions a role for serotonin in the development of glaucoma and diabetic retinopathy might be suspected. In a series of pilot studies on rats the effects of serotonin on the anterior and posterior segments of the eye were studied. Serotonin had marked influence on the retinal and choroidal vasculature. The optic disk seemed to be very sensitive to serotonin. Possibly it had an influence on the blood-retinal barrier. It caused transient cataracts, probably by decreasing the production of aqueous. It blocked tropicamin-induced mydriasis. The techniques and provisional results of measurement of serotonin in human aqueous are also described.

show abstract