Untersuchungen über gemischte Methenyl‐verbindungen. IV: Synthese des α, β′‐Lutidins

Errera, G.

doi:10.1002/cber.19010340367

Cited by 5 publications

(1 citation statement)

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“…The characteristic of reactions in the solution is that all of them happened in numerous stages, so the overall yield is modest. Some of the most representative examples are synthesis via 3-carbetoxy-2,5--dimethyl-6-hydroxypyridine (the overall yield 8 %), 7 cyclic condensation via 3-carbetoxy-2,5-dimethylpyridine (the overall yield 22 %). 8 Direct synthesis of collidine from mono-substituted acetylenes and nitriles in the presence of cobaltocene was achieved (yield in this step 45%), and the composition of the reaction mixture was estimated using gas-liquid chromatography (GLC).…”

Section: The Synthesis Of 235-trimethylpyridine In the Gaseous Phasementioning

confidence: 99%

Optimization of the reaction conditions for the synthesis of 2,3,5-trimethylpyridine from 3-amino-2-methylpropenal and methylethylketone

Urosevic¹,

Mitic²,

Arsić

et al. 2022

JSCS

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It was investigated the influence of temperature, reaction time, and type of the catalyst on the yield of the 2,3,5-trimethylpyridine (collidine) from 3-amino-2-methylpropenal and methylethylketone. 3-Amino-2-methylpropenal was synthesized from 3-ethoxy-2-methylacrolein previously synthesized from methylmalondialdehyde tetraethyl acetal, obtained from triethyl orthoformate and propenyl ether. The found optimal conditions for the synthesis were a temperature of 150 ?C, reaction time 24 h, and the catalyst CH3COOH/pTsOH. This synthesis is the first successful attempt to synthesize 2,3,5-trimethylpyridine in an acid medium.

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Section: The Synthesis Of 235-trimethylpyridine In the Gaseous Phasementioning

confidence: 99%