Untersuchungen über die Wirkung des Atoxyls auf die Syphilis¹)

Abstract

Nachdem von einer Reihe von Autoren die Wirkung desAtoxyls auf verschiedene Trypanosomenarten, besonders die Erreger der Schlafkrankheit und der Dourine festgestellt wor-

Chemical Structure Elucidation in the Development of Inorganic Drugs: Evidence from Ru‐, Au‐, As‐, and Sb‐based Medicines

“…Early studies showed that arsanilic acid was indeed effective but exhibited undesired side effects. [86] To find yet further improved drugs, a research program was launched in which the arsanilic acid framework was systematically varied in terms of its molecular structure and antisyphilitic activity was recorded as a function of these variations. Because of the consideration that was given to synthesis of molecules of specified targeted structures, this endeavor can justifiably be viewed as the advent of modern medicinal chemistry.…”

“…This discovery led investigators to propose that syphilis might be amenable to treatment using the types of antiparasitic drugs that had proven effective against trypanosomiasis. Early studies showed that arsanilic acid was indeed effective but exhibited undesired side effects [86] . To find yet further improved drugs, a research program was launched in which the arsanilic acid framework was systematically varied in terms of its molecular structure and antisyphilitic activity was recorded as a function of these variations.…”