Untersuchungen über die periphere Wirkung des Physostigmins

Fühner, H.

doi:10.1007/bf01982670

Cited by 12 publications

(6 citation statements)

References 8 publications

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“…Indeed, the cala bar bean, Ph y sostigma venenosum, was used for centu ries in tribal rites of Western Africa and as an antidote of curare in South America (Karczmar 1970;Holmstedt 1972;Holmstedt et al 1984). Subsequently, as the bean Fuhner (1917) and Loewi with Navratil (1926;see Karczmar 1970;Holmstedt 1972). Feldberg 1987).…”

Section: Precholinergic Eramentioning

confidence: 99%

Brief Presentation of the Story and Present Status of Studies of the Vertebrate Cholinergic System

Karczmar

1993

Neuropsychopharmacol

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This year marks the seventieth anniversary of Otto Loewi's demonstration of chemical transmission generally and autonomic cholinergic transmission specifically and the fortieth anniversary of John Eccles's proof of the existence of central cholinergic transmission. Following these epochal findings, the subsequent studies of the cholinergic system led to discoveries of similarly important phenomena. This review concerns these phenomena, including chemical structure and molecular biology of cholinergic receptors; electrophysiologic and ionic aspects of pre-and postsynaptic cholinergic events; the quantal expression of cholinergic postsynaptic events and activities of their subunits, the elementary events; and teratology; trophic phenomena; and the clinical aspects of the cholinergic system. This review refers to the history as well as the present status of each of these phenomena; furthermore, it describes briefly the nineteenth-century work with calabar bean, pilocarpine, muscarine, and nicotine, that is, the work performed before the promulgation of the cholinergic era.[ Neuropsychopharmacology 9:181-199, 1993J included the frrst descriptions of the trophic phenomena, the quantal nature of the biological events, the recep tors and their chemical structure, the role of a trans mittive system in arousal and memory, and so on. So, it is appropriate to sketch at this time the history and the present status of the vertebrate cholinergic studies.

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Section: Precholinergic Eramentioning

confidence: 99%

Brief Presentation of the Story and Present Status of Studies of the Vertebrate Cholinergic System

Karczmar

1993

Neuropsychopharmacol

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“…The L-shaped rod to which the muscle is attached, serves at this time as an air or oxygen vent." This setup, used by the late T. Koppanyi since the thirties is essentially identical with Fuhner's (1918) bioassay apparatus which he used to demonstrate physostigmine potentiation of acetylcholine response of smooth muscle and which was used by Loewi (1921) to identify ACh in the heart perfusate (see Karczmar, 1970).…”

Section: Discussionmentioning

confidence: 99%

“…The effects of VX on the glutamate-activated single channel currents were determined from noise analysis experiments performed in the locust of EPSCs recorded from the same~oup of FTiM fibers before «(), 4-7 EPSCs) and after 10 ).1M VX <., [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. neuromuscular preparat ion.…”

Section: Dfp and Tabun Inducedmentioning

confidence: 99%

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Neurobiology of Acetylcholine

Dun¹,

Perlman²,

Karczmar³

1987

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“…Additional advances in the knowledge of the brain were made in the XIX th Century by the German medical men and physiologists, particularly the students of Johannes Mueller and Karl Ludwig, Karl Wernicke (1848-1904), Gustav Fritsch (1838), Korbinian Brodmann (1868-1918 and Eduard Hitzig . Wernicke and his predecessor the French physician Pierre Paul Broca (1824-1880) established the language and the speech center (Broca's area) and further localization of functions and behaviors in the brain was provided by Fritsch, Hitzig and Brodmann, the latter particularly with regard to the cortical localization of functions.…”

Section: Early Story Of the Autonomic And Central Nervous Systemmentioning

confidence: 99%

<b>Story of Muscarinic Receptors, Alkaloids with Muscarinic Significance and of Muscarinic Functions and Behaviors</b>

Karczmar

2009

Annu Rev Biomed Sci

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This review of the studies of the muscarinic receptors, their synaptic activities and their functional and behavioral roles will begin with the history of the research of the autonomic and central nervous systems and their transmitters, the development of the notion of the receptor, and the tale of the significance of muscarine and other alkaloids as well as of organophosphorus (OP) anticholinesterases for these studies; we will then segue into the modern status of muscarinic receptors and of their functional and behavioral expression.

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Untersuchungen über die periphere Wirkung des Physostigmins

Cited by 12 publications

References 8 publications

Brief Presentation of the Story and Present Status of Studies of the Vertebrate Cholinergic System

Brief Presentation of the Story and Present Status of Studies of the Vertebrate Cholinergic System

Neurobiology of Acetylcholine

<b>Story of Muscarinic Receptors, Alkaloids with Muscarinic Significance and of Muscarinic Functions and Behaviors</b>

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