<b>Story of Muscarinic Receptors, Alkaloids with Muscarinic Significance and of Muscarinic Functions and Behaviors</b>

Abstract

This review of the studies of the muscarinic receptors, their synaptic activities and their functional and behavioral roles will begin with the history of the research of the autonomic and central nervous systems and their transmitters, the development of the notion of the receptor, and the tale of the significance of muscarine and other alkaloids as well as of organophosphorus (OP) anticholinesterases for these studies; we will then segue into the modern status of muscarinic receptors and of their functional and behavioral expression.

Muscarine, imidazole, oxazole, and thiazole alkaloids

“…Muscarine mimics the action of acetylcholine at muscarinic acetylcholine receptors, which were named after it. 21 On the basis of genetic and pharmacological characterizations the receptors have been further classified into five subtypes, termed M 1 -M 5 .…”

<b>EDITORIAL: The Special Issue “Cell Receptors and Signaling”</b>

“…The volume starts with a detailed and interesting historical overview of the cholinergic system written by Dr. Alexander G. Karczmar; from the early anatomical studies and application of medicinal plants with cholinergic properties, by shamans, hunters, medicine men and mystics, to the latest discussion of the contribution of muscarinic acetylcholine receptor, members of the G protein-coupled receptor (GPCR) superfamily, to behavioral, psychological and mental function (Karczmar, 2009). Dr. Karczmar is Professor Emeritus of Pharmacology at Loyola University Medical Center, USA, and has devoted more than 6 decades of his life studying various aspects of the cholinergic nervous system.…”

Η Βιοπαιδαγωγική-Διδακτική Αρχή Της Εμπέδωσης Στο Μάθημα Της Βιολογίας

“…"Nicotine dependence: development, mechanisms, individual differences and links to possible neurophysiological correlates." Wiener Klinische Wochenschrift, 115(5-6):155-160 • Karczmar, A.G. (2009). "Story of Muscarinic Receptors, Alkaloids with Muscarinic Significance and of Muscarinic Functions and Behaviors."…”