Muscarine, imidazole, oxazole, and thiazole alkaloids

Jin, Zhong

doi:10.1039/c0np00074d

Cited by 287 publications

(117 citation statements)

References 457 publications

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“…206,207 Very few biosynthetic studies have been performed on this class of compounds. Sponge-associated metabolites present difficult challenges for biosynthetic studies because many of the strains are uncultivatable, precluding in vivo studies.…”

Section: N–o Bond Forming Enzymesmentioning

confidence: 99%

Heteroatom–Heteroatom Bond Formation in Natural Product Biosynthesis

et al. 2017

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Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X, where X = N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and diversity of these structural motifs has captured the interest of synthetic and biological chemists alike. Functional groups containing X–X bonds are found in all major classes of natural products and often impart significant biological activity. This review presents our current understanding of the biosynthetic logic and enzymatic chemistry involved in the construction of X–X bond containing functional groups within natural products. Elucidating and characterizing biosynthetic pathways that generate X–X bonds could both provide tools for biocatalysis and synthetic biology, as well as guide efforts to uncover new natural products containing these structural features.

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Section: N–o Bond Forming Enzymesmentioning

confidence: 99%

Heteroatom–Heteroatom Bond Formation in Natural Product Biosynthesis

et al. 2017

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“…More generally thiazolines and oxazolines, as well as their oxidized forms (thiazoles and oxazoles), are found in a variety of approved drugs, drug leads, and toxins. [2] The cyanobacterium Prochloron spp. produces multiple macrocyclic cyanobactins, which are known as the trunkamides (seven or eight residues) and the patellamides (eight residues).…”

mentioning

confidence: 99%

The Cyanobactin Heterocyclase Enzyme: A Processive Adenylase That Operates with a Defined Order of Reaction

et al. 2013

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Rückwärts zählen: Die Cyanobactin‐Klasse der Heterocyclasen, mit TruD als Beispiel, zeichnet sich durch eine nahezu einzigartige Kombination von Prozessivität, Spezifität, chemischer Vielseitigkeit und Promiskuität aus. Biochemische Assays zeigen, dass TruD eine Adenylase ist und Cysteine prozessiert. Selbst wenn die komplette Führungssequenz des Substrats entfernt wird, kann TruD einen einzelnen spezifischen Cysteinrest prozessieren; die Funktion der Führungssequenz besteht aber in der Aufrechterhaltung der Prozessivität durch Ausbalancieren der molekularen Erkennung.

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“…As a result, both the introduction of new methodologies and the developments of the already reported synthesis of imidazoles have created great interest in universities' research laboratories as well as in industry. Consequently, an increasing amount of worldwide research has grown in the area of synthesis, functionalization, and derivatization of the imidazole scaffold [8][9][10][11][12][13][14][15][16][17][18][19][20][21]. A literature survey revealed several useful reviews on the synthesis of imidazoles [22][23][24][25][26]-among them a comprehensive review published in Tetrahedron in 2007 [22].…”

Section: Introductionmentioning

confidence: 99%