Untersuchungen über die Folgen einer chronischen Verabreichung akut toxischer Dosen von Natriumcyanid an Hunden

Hertting, G.; Kraupp, O.; Schnetz, E; Wuketich, S

doi:10.1111/j.1600-0773.1960.tb01228.x

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…Acute cyanide intoxication is reported to cause severe encephalitis, which was subsided using anticyanide and anti-inflammatory treatments (Dogan et al, 2006). Chronic inflammation has been reported in the intestine of dogs exposed to ≥0.27 mg cyanide/kg/day for 14.5 months (Hertting et al, 1960). Chronically cyanide exposed dogs also showed histological degenerative changes in ganglion cells and especially in Purkinje cells in the cerebellum due to necrosis and inflammation (Hertting et al, 1960).…”

Section: Discussionmentioning

confidence: 99%

“…Chronic inflammation has been reported in the intestine of dogs exposed to ≥0.27 mg cyanide/kg/day for 14.5 months (Hertting et al, 1960). Chronically cyanide exposed dogs also showed histological degenerative changes in ganglion cells and especially in Purkinje cells in the cerebellum due to necrosis and inflammation (Hertting et al, 1960). In the present study, we observed increased levels of pro-inflammatory cytokines in brain tissue homogenates, which agrees well with the reported literature.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy assessment of co-treated alpha-ketoglutarate and N-acetyl cysteine against the subchronic toxicity of cyanide in rats

et al. 2019

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Cyanide is an important industrial pollutant, major occupational hazard, and a potential chemical warfare agent. Its intentional or accidental exposure to humans is a big clinical problem because of its rapid mode of action. Certain plant origin foods also contain substantial amount of cyanide and cause chronic toxicity. This study explores the protective efficacy of co-treatment of alpha-ketoglutarate (AKG) and an antioxidant N-acetyl cysteine (NAC) against toxicity of subchronically exposed cyanide in rats. We explore the effect of AKG + NAC co-treatment on oxidative stress, inflammation, and histological changes induced due to long-term sublethal cyanide exposure. Cyanide induces oxidative stress by inhibiting metalloenzymes (catalase and superoxide dismutase) causing increase in lipid peroxidation (malondialdehyde) and decrease in reduced glutathione (GSH). It also increases the activity of cyclo-oxygenase enzymes causing oxidative stress-mediated inflammation in the brain. Cyanide exposure also causes degenerative changes in the brain as shown in histology. It also causes pathology in liver and kidney. AKG is known to form cyanohydrins with cyanide reducing the free cyanide levels, and its combination with NAC showed overall improvement in by reducing the oxidative stress and subsequent neuroinflammation. Their combination was also found to improve the histological outcome of vital tissues. AKG, an over-the-counter sport medicine, and the antioxidant NAC per se did not show any detrimental effects in any tested parameter. Hence, oral treatment with AKG and NAC can be beneficial for the treatment of chronic cyanide poisoning.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy assessment of co-treated alpha-ketoglutarate and N-acetyl cysteine against the subchronic toxicity of cyanide in rats

et al. 2019

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“…No se ha observado efectos adversos en perros expuestos a cianuro de sodio ingerido con la dieta a las dosis de 3 mg/ kg de peso/día por 30 y 32 días (38) .…”

Section: En Animales De Experimentaciónunclassified

Toxicidad del cianuro. Investigación bibliográfica de sus efectos en animales y en el hombre

Ramírez

2011

An Fac med

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REVISIÓN La prevención, el mejor antídotoResumen Se llama cianuro al cianuro en sí, al cianuro de hidrógeno y a sus sales. Los cianuros existen en forma natural e industrialmente se les obtiene como sales. Aún a dosis bajas son compuestos letales en tiempo mínimo de exposición. El sistema nervioso es su órgano blanco primario. Luego de ingestión, inhalación o contacto se presentan efectos neurotóxicos graves y mortales en humanos y animales. La exposición ocupacional produce alteraciones tiroideas, cefalea, vértigo, vómito, náuseas, dermatitis y exposiciones altas; a corto tiempo, terminan en paro respiratorio y muerte. Algunos compuestos de cianuro en microcantidades son indispensables para la vida. Respecto a su poder carcinógeno, al cianuro se le considera en el grupo D de los 'no clasificables como carcinógenos humanos'. Para aplicar mejor las medidas preventivas en el trabajo con cianuros, y en salud pública, es necesario conocer satisfactoriamente su acción tóxica sobre los animales y el hombre. Palabras clave: Cianuros; exposición ocupacional; acciones tóxicas; neurotóxicos. AbstractCyanide, hydrogen cyanide and its salts are called cyanide. They exist in natural form and are obtained as salts in industry. At low doses they are lethal in minimum exposure time. The nervous system is its primary target organ. After ingestion, contact or inhalation, serious neurotoxic effects appear in humans and animals. Occupational exposure can produce headache, vertigo, vomiting, nausea, thyroid gland alterations, and dermatitis. At high doses and in short time, cyanide exposure can end in death. In very low amounts some cyanide compounds are indispensable for life. Cyanide is located in group D "not classifiable as human carcinogen". In order to apply preventive measures when working with cyanides and in public health, it is necessary to acknowledge cyanide toxic effects on men and animals.

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Chemical Warfare Agents: Estimating Oral Reference Doses

Opresko

Young

Faust

et al. 1998

Reviews of Environmental Contamination and Toxicology

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Untersuchungen über die Folgen einer chronischen Verabreichung akut toxischer Dosen von Natriumcyanid an Hunden

Cited by 7 publications

References 21 publications

Efficacy assessment of co-treated alpha-ketoglutarate and N-acetyl cysteine against the subchronic toxicity of cyanide in rats

Efficacy assessment of co-treated alpha-ketoglutarate and N-acetyl cysteine against the subchronic toxicity of cyanide in rats

Toxicidad del cianuro. Investigación bibliográfica de sus efectos en animales y en el hombre

Chemical Warfare Agents: Estimating Oral Reference Doses

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