Untersuchungen über den Natriumgehalt der Erythrozyten bei Normo- und Hypertonikern mit familiärer Hochdruckbelastung

Wessels, F; Losse, H; Zumkley, H

doi:10.1007/978-3-642-88217-3_51

Cited by 9 publications

(11 citation statements)

References 5 publications

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“…Thus, it could be shown that sodium sensitivity in experimental hypertension appears to be related to transmembrane ionic transport abnor malities noted in the smooth muscle cells of spontane ously hypertensive rats [Yamori et al, 1982]. In 1966, we found a disturbance in the sodium metabolism of red blood cells not only in patients with established primary hypertension but also in the normotensive offspring of hypertensive parents [Wessels et al, 1966]. In this investi gation it could be observed that the sodium content of red blood cells was already increased in the offspring of hypertensives with normal blood pressure.…”

Section: Discussionmentioning

confidence: 62%

Taste Sensitivity for Sodium Chloride in Hypotensive, Normotensive and Hypertensive Subjects

Zumkley¹,

Vetter²,

Mandelkow³

et al. 1987

Nephron

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The taste sensitivity for sodium chloride was examined in 103 normotensive, 55 hypertensive and 36 hypotensive subjects. The examination was performed on five areas of the tongue using four different concentrated NaCl solutions (2.5, 5,0, 7.5 and 15%). The results indicate that hypotensive subjects show a much higher salt sensitivity compared to normotensive or hypertensive subjects. The enhanced sensitivity of hypotensives to sodium chloride may reflect a regulatory factor tending to normalize blood pressure. In contrast, the lower sensitivity of hypertensives points to a salt dependency of high blood pressure in these patients.

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Section: Discussionmentioning

confidence: 62%

Taste Sensitivity for Sodium Chloride in Hypotensive, Normotensive and Hypertensive Subjects

Zumkley¹,

Vetter²,

Mandelkow³

et al. 1987

Nephron

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“…'• 2 Ideally, genetic markers for essential hypertension could permit recognition of different forms of the disease, allow early detection of hypertension, and assist in the study of pathogenesis of the disorder.- 1 Alterations in cellular properties (mainly of blood cells) have been described in humans and in animal models in association with essential hypertension. 4 …”

Section: Ssential Hypertension Apparently Resultsmentioning

confidence: 99%

Essential hypertension: improved differentiation by the temperature dependence of Li efflux in erythrocytes.

Lévy¹,

Paran²,

Keynan³

et al. 1983

Hypertension

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SUMMARY Kinetic and thermodynamic properties of red cell lithium (Li) efflux were examined in patients with essential hypertension; the maximal rate of Li efflux as affected by temperature was measured at the range of 12° to 42°C. Fifty-two patients with essential hypertension and 22 normotensives were studied. The mean Li efflux, both into sodium (Na) medium and Ll-Na countertransport, was higher in hypertensive than in normotensive persons, but the distinction between the two groups was limited by extended scatter and overlap. The distinction could be markedly improved by determining the effect of temperature on Li efflux. While all the normotensives exhibited Arrhenius plots of Li efflux with a change in slope ("break") around 30°C, the corresponding "break" for most (75%) of the hypertensives was about 20°C. Consideration of both the rate and the temperature dependence of Li efflux further improved the differentiation of hypertensive patients. Analysis of normotensive offspring of hypertensives and of patients with secondary hypertension indicates that the temperature dependence of Li efflux may serve as a genetic marker for essential hypertension. 10 Furthermore, two erythrocyte transport systems, Li-Na countertransport" and Na-K cotransport, 12 have been reported as possible genetic markers of essential hypertension. These transport assays appear useful in distinguishing between essential and secondary hypertension and for detection of predisposition for hypertension among offspring of affected parents.3 "" 22 Yet, certain difficulties may limit the application of the transport assays in the present form. Li-Na countertransport and Na-K cotransport exhibit marked interindividual differences even within the

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“…Indirect evidence for an association of RBC transport abnormalities and vascular smooth muscle cell dysfunction in essential hypertension was reported in the 1960s by Losse, Wessels, and their co-workers, who found RBC sodium content* and the rate of "Na* influx 7 to be slightly elevated in RBCs from hypertensive subjects. Postnov et al 8 described a similar increase in ^a" 1 " efflux from the RBCs of essential hypertensive subjects and presented evidence that the cause of the increased "Na + permeability is a defect in 18 have investigated the relationship between RBC countertransport and vascular resistance, and they reported a positive correlation of modest strength (r = 0.46, p<0.02).…”

Section: Summary Red Blood Cell LImentioning

confidence: 98%

Red blood cell Li+-Na+ countertransport, Na+-K+ cotransport, and the hemodynamics of hypertension.

Weder¹,

Fitzpatrick

Torretti

et al. 1987

Hypertension

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SUMMARY Red blood cell Li+ -Na + countertransport and Na + -K + cotransport activities, home blood pressure, invasive systemic hemodynamics, and limb venous compliance were measured in 65 white men (23 normotensive, 22 borderline hypertensive, and 20 mild essential hypertensive subjects). Li + -Na + countertransport activity was positively and significantly correlated with subject-determined home systolic blood pressure (r = 0.31, p < 0.02) and with directly measured systolic (r = 0.29, p<0.02) and diastolic (r=0.27, p<0.03) blood pressures in the hemodynamic laboratory, independent of potential confounding variables. Analysis of the hemodynamic determinants of blood pressure revealed a significant positive correlation of countertransport with vascular resistance (r=0.30, p<0.02) but not with cardiac output or cardiac index. High red blood cell Na + -K + cotransport activity was not independently associated with hypertension or with a characteristic hemodynamic pattern but was related to decreased venous compliance. Red blood cell Li + -Na + countertransport deserves further study as a marker for the genetic substrate of human essential hypertension. Red cell Na + -K + cotransport may be altered secondarily by factors related to high blood pressure and seems to be a valid marker for abnormalities of the venous system in hypertension. (Hypertension 9: 459-466, 1987) KEY WORDS • lithium-sodium countertransport • sodium-potassium cotransport bumetanide • vascular resistance • venous compliance I NCREASED systemic vascular resistance is the hemodynamic hallmark of established human essential hypertension. Borderline hypertension results from elevated cardiac output in about a third of patients, but even in such "hyperkinetic" hypertensive patients, vascular resistance is considered to be inappropriately elevated for the prevailing cardiac output.' Although structural changes may reinforce and amplify the development of elevated vascular resistance, 2 the events initiating hypertension can more plausibly

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Untersuchungen über den Natriumgehalt der Erythrozyten bei Normo- und Hypertonikern mit familiärer Hochdruckbelastung

Cited by 9 publications

References 5 publications

Taste Sensitivity for Sodium Chloride in Hypotensive, Normotensive and Hypertensive Subjects

Taste Sensitivity for Sodium Chloride in Hypotensive, Normotensive and Hypertensive Subjects

Essential hypertension: improved differentiation by the temperature dependence of Li efflux in erythrocytes.

Red blood cell Li+-Na+ countertransport, Na+-K+ cotransport, and the hemodynamics of hypertension.

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