Naunyn Schmiedebergs Archiv Für Pharmakologie 1969
DOI: 10.1007/978-3-662-39718-3_17
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Untersuchungen über den Mechanismus der Blutdruckwirkung des Anaphylatoxins bei Katzen und Meerschweinchen

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Cited by 3 publications
(2 citation statements)
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“…As we have shown, noradrenaline is liberated by AT, and this effect is mepyramine-resistant. Findings of Bodammer [1969] and H icks and Sackeyfio [1972] strongly support the idea that, besides adrenaline release from the adrenal me dulla, an activation of sympathetic neurons occurs in AT shock.…”
Section: Discussionsupporting
confidence: 63%
“…As we have shown, noradrenaline is liberated by AT, and this effect is mepyramine-resistant. Findings of Bodammer [1969] and H icks and Sackeyfio [1972] strongly support the idea that, besides adrenaline release from the adrenal me dulla, an activation of sympathetic neurons occurs in AT shock.…”
Section: Discussionsupporting
confidence: 63%
“…in vivo, C5a-desArg and even C3a-desArg has considerable po tency [20,21], Under these conditions, helper factors may assist in the effects [22], Many of the biological actions of anaphylatoxins are rather indirect, and require the cooperation of more than one target cell and of cell-derived mediators. Smooth muscle contraction is partially mediated by mast cell-derived histamine [23], by prostaglan dins and by leukotrienes [24], Various smooth muscle organs are certainly con tracted by C5a independent of histamine [25,26]; however, a clearly direct response to C5a has as yet been demonstrated in one target only -isolated muscle cells from toad stom ach [27], Vascular smooth muscle may be contracted [24,[28][29][30] or relaxed [31,32] depending on the type of blood vessel. This could be due to the involvement of second mediators released in different ratios, and then causing different net effects.…”
mentioning
confidence: 99%