Untersuchungen mit dem Adrenostatikum Su 4885 (Metopiron) in der Schwangerschaft

Heinen, G; Buchheit, H.; Oertel, G. W.

doi:10.1007/bf01583748

Cited by 3 publications

(1 citation statement)

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“…The drug appeared to inhibit the release of surfactant in baboons, although the infants did not develop respiratory distress (Kling & Kotas, 1975). In pharmacological studies, in the normal human, administration of metyrapone for 6 days in late pregnancy did not result in adverse effects on the fetus or the mother (Heinen et a[., 1963). In our patient the fetal growth, as measured by the biparietal skull diameter, and fetal wellbeing were satisfactory and at delivery the infant had no signs of adrenal insufficiency.…”

Section: Discussionmentioning

confidence: 49%

Cushing's Syndrome in Pregnancy—treatment With Metyrapone

Gormley

Hadden

Kennedy

et al. 1982

Clinical Endocrinology

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A 23-year-old female presented with severe Cushing's syndrome in the 23rd week of pregnancy. Investigations showed plasma cortisol 770 nmol/l (08.00 h) and 850 nmol/l (23.00 h); plasma ACTH was 10 ng/l (08.00 h) and 27 ng/l (23.00 h); urinary free cortisol excretion was 2460 nmol/24 h. Dexamethasone 2 mg 6-hourly for 48 h suppressed the 08.00 h plasma cortisol only to 680 nmol/l. Abdominal C.T. scan showed a right adrenal adenoma. The patient was treated with metyrapone and a good clinical improvement ensued. Plasma cortisol was reduced to 300-500 nmol/l. Depsite ultrasonographic evidence of normal fetal growth, urinary oestriol excretion was markedly deficient. Prior to the spontaneous onset of labour, there was a marked rise in plasma cortisol despite continuous metyrapone treatment. A normal female infant was born at 37 weeks' gestation. The maternal adrenal adenoma was subsequently removed. The deficiency of oestriol synthesis during the pregnancy may be explained by metyrapone-induced inhibition of C19-hydroxylation.

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Section: Discussionmentioning

confidence: 49%