Inhibitors of adrenal cortical function

Gaunt, Richard A.; Chart, J. J.; Renzi, A. A.

doi:10.1007/bfb0117430

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Inhibitors Of Steroid Secretion2

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Cited by 19 publications

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“…This is followed, as a result of the release from cortisol inhibition, by an enhanced ACTH output. With normal pathways of steroidogenesis blocked, the effect of ACTH is to increase the output of two normally minor lI-deoxy steroids: lI-deoxycortisol and lI-deoxycorticosterone (GAUNT et al, 1965).…”

Section: Inhibitors Of Steroid Secretionmentioning

confidence: 99%

“…A number of compounds are listed below (a larger list is more extensively discussed elsewhere - GAUNT et al, 1965), which, because of their mode of action, could potentially have some use in selected cases of hypertensive disease. With the exception of o,p'-DDD (mitotane), however, which has other demonstrated uses, these compounds have served largely as experimental tools in animal experimentation; clinical study has been either lacking or scanty.…”

Section: Inhibitors Of Corticosteroid Secretion Of Potential Intementioning

confidence: 99%

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