Effects of metopirone on the structure of endocrine glands in the male lizard, Cnemidophorus l. lemniscatus (L.)

Conte, Estanislao Del

doi:10.1007/bf00307085

Z.Zellforsch

1972

DOI: 10.1007/bf00307085

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Effects of metopirone on the structure of endocrine glands in the male lizard, Cnemidophorus l. lemniscatus (L.)

Estanislao Del Conte

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Cited by 14 publications

References 43 publications

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The subacrosomal granule and its evolution during spermiogenesis in a lizard

1976

Cell Tissue Res.

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Some aspects of spermiogenesis have been studied in the testis of the teiid lizard Cnemidophorus lemniscatus lemniscatus by electron microscopy. Shortly after the acrosomal vesicle is lodged in a nuclear concavity of the spermatid, a dense granule differentiates in the center of the subacrosomal space. It is cone-shaped and shows a longitudinal striation. Its base applies to the acrosomal membrane and, through this, to the acrosomal granule. Its rounded vertex causes a depression of the nuclear membranes which, initially juxtaposed, separates at this point to form a vesicle. The granule develops and becomes a rod when spermiogenesis is advanced and the subacrosomal space has taken the form of a secondary cap. The rod is cylindrical, retains its original striation and has a convex acrosomal end. It encloses the vesicle formed by the nuclear envelope in its base and follows the apex of the nucleus. Meanwhile, the acrosomal granule loses its identity and the acrosomal cap is filled with a dense substance, in which a fringe of translucent material differentiates. This fringe lies in the dorsal and apical margins of the acrosome and is incompletely divided by longitudinal crests of the dense acrosomal substance. A projection of the Sertoli cell forms an accessory cap which envelops the acrosome and is in turn covered by the cytoplasm of the spermatid, constituting an intricate association. Two reflex membranes underlie the plasmalemma in the outer surface of the projection of the Sertoli cell. They are continuous with one another at their ends and with the cell membrane in the edge of pores. In the peripheral cytoplasm of the spermatid facing the accessory cap, numerous microtubules run longitudinally. By means of thin membranes some are interconnected or connected with the plasmalemma, from which they seem to originate.

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The subacrosomal granule and its evolution during spermiogenesis in a lizard

1976

Cell Tissue Res.

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Correlated changes in the structure of the anterior pituitary gland, testes and interrenal tissue during sexual maturation of male lizards

1975

Cell Tissue Res.

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The anterior pituitary gland, testes and interrenal glands of a series of young males of the teiid Cnemidophorus l. lemniscatus (L.) have been studied by light microscopy in order to correlate the changes occurring during sexual maturation. In the testes of the smallest animals, spermatogenesis does not progress beyond primary spermatocytes and there is no differentiated interstitial tissue. In medium-sized animals, spermatids and some interstital cells appear, and in the largest lizards, spermatogenesis is completely established and Leydig cells abound. Simultaneously with the development of the testes, interrenal glands undergo great hypertrophy and hyperplasia, especially in the peripheral reactive zone. Starting in animals of intermediate size, the anterior hypophysis exhibits a considerable hypertrophy of two rostral cell types: the chromophobic corticotrophs and the acidophilic PAS-positive cells considered to be interstitiotrophs, These cells show large, vesicular nuclei and prominent nucleoli, signs of enhanced cellular activity. The hypertrophy begins in the dorso-rostral region of the gland close to the median eminence, at the site of entry of the portal vessels. This suggests a hypothalamic influence on the function of these pars distalis cells. The scattered basophilic gonadotrophs or folliculotrophs are scarce, small, and do not vary appreciably among the animals studied. The hyperactivity of corticotrophs may account for enlargement of the interrenal glands. Testicular development is apparently related to an increased activity of interstitiotrophs but to a stable level of activity in folliculotrophs.

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Adenohypophysial cell-types in the pituitary gland of the soft-shelled turtle, Trionyx sinensis

Yip

Lofts

1976

Cell Tiss. Res.

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By using various staining techniques, two acidophilic and three basophilic cell-types have been distinguished in the pars distalis of Trionyx sinensis. Seasonal fluctuations in their cytoplasmic granulation, cell and nuclear size have been compared with seasonal patterns of activity in the gonads, adrenals and thyroid. On the basis of the results, specific functions have been ascribed to each cell-type. Basophils 1 activity closely parallels the seasonal thyroid cycle. Basophils 2 are probably FSH-secreting gonadotropes and their activity correlates with the seasonal cycle of spermatogenesis in the seminiferous tubules. The functional activity of the testicular interstitial cells correlates with the secretory pattern of the basophils 3. That these are LH-secreting cells is also suggested by the epididymidal cycle, which indicates a high level of androgen secretion coincident with the rapid degranulation of these cells, at a time of no spermatogenetic activity. Adrenal activity shows no relationship with the basophils 3 cycle, and chromophobic cells may be the locus of ACTH secretion. Acidophils 2 remain stable throughout the year and are probably somatotropes, but acidophils 1 increase their activity in autumn and are likely to be lactotropes.

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Effects of metopirone on the structure of endocrine glands in the male lizard, Cnemidophorus l. lemniscatus (L.)

Cited by 14 publications

References 43 publications

The subacrosomal granule and its evolution during spermiogenesis in a lizard

The subacrosomal granule and its evolution during spermiogenesis in a lizard

Correlated changes in the structure of the anterior pituitary gland, testes and interrenal tissue during sexual maturation of male lizards

Adenohypophysial cell-types in the pituitary gland of the soft-shelled turtle, Trionyx sinensis

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