“…The results of the cytotoxicity assays are in good agreement with MS data obtained from alkylation of duplex DNA with (+)-(1S,10R)-2 a, (+)-(1S,10R)-3, and (À)-(1R,10S)-3. [19] As a further important finding from the cytotoxicity assays in vitro, it should be emphasized that after treatment of prodrug (+)-(1S,10R)-2a with b-d-galactosidase, the observed cytotoxicity was identical to that determined for seco compound (+)-(1S,10R)-3. …”