Untersuchung der Pentagastrinwirkung auf die Sekretion des Rattenmagens

Klein, H. J.; Gheorghiu, T; Frotz, H; Eder, M.

doi:10.1007/bf02044244

Cited by 6 publications

(1 citation statement)

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“…Ebenso wie an nichtvagotomierten Ratten [2,10,15] tritt auch an l~atten mit Vagotomie bei steigender Pentagastrindosierung eine Hemmung der S~uresekretion auf, die sich in unseren Versuchen in einem Absinken der HC1-Sekretion bei Pentagastrindosen oberhalb 10 ~g/100gKG…”

Section: Diskussionunclassified

Wirkung steigender Pentagastrindosen auf die Säuresekretion des Rattenmagens nach Vagotomie im Perfusionsversuch

Struve

Hantschmann

1974

Res. Exp. Med.

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Male Wistar rats were subjected to a eomplege bilateral vagotomy and a pyloroplasty. 4 weeks later followed in urethane anesthesia a continuous perfusion of the stomach with 0.9~/o saline according to the rat preparation of Ghosh. The completeness of the gastric vagotomy was confirmed by a postoperative insulin test. In an interval of 150 min the rats --in 6 groups of 10 rats each --were two times injected pentagastrin subcutaneously in dose rates of 50, 100, 150, 250 or 300 lzg/kg body weight. The statistical confirmed results can be summarized as followed:1. The second injection of pentagastrin --150 min after the first --in the same dose produced a significantly higher gastric acid secretion in the rat all dose rates in comparison to the first injection.2. The maximal gastric acid secretion was produced by a dose rate of 100 lzg/kg body weight of pentagastrin. At higher dose rates of pentagastrin there was a significant reduction of gastric acid secretion.Zusammen/assung. Bei m/innliehen Wistarratten wurde eine trunkuliire beider.Schli~sselw6rter: Gastrinpentapeptid --Vagotomie --S~uresekretion --Perfusionsversueh --Ratte. 19"

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Section: Diskussionunclassified