Wirkung steigender Pentagastrindosen auf die Säuresekretion des Rattenmagens nach Vagotomie im Perfusionsversuch

Abstract

Male Wistar rats were subjected to a eomplege bilateral vagotomy and a pyloroplasty. 4 weeks later followed in urethane anesthesia a continuous perfusion of the stomach with 0.9~/o saline according to the rat preparation of Ghosh. The completeness of the gastric vagotomy was confirmed by a postoperative insulin test. In an interval of 150 min the rats --in 6 groups of 10 rats each --were two times injected pentagastrin subcutaneously in dose rates of 50, 100, 150, 250 or 300 lzg/kg body weight. The statistical confirmed results can be summarized as followed:1. The second injection of pentagastrin --150 min after the first --in the same dose produced a significantly higher gastric acid secretion in the rat all dose rates in comparison to the first injection.2. The maximal gastric acid secretion was produced by a dose rate of 100 lzg/kg body weight of pentagastrin. At higher dose rates of pentagastrin there was a significant reduction of gastric acid secretion.Zusammen/assung. Bei m/innliehen Wistarratten wurde eine trunkuliire beider.Schli~sselw6rter: Gastrinpentapeptid --Vagotomie --S~uresekretion --Perfusionsversueh --Ratte. 19"