2016
DOI: 10.1186/s13071-016-1907-5
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Untangling the transmission dynamics of primary and secondary vectors of Trypanosoma cruzi in Colombia: parasite infection, feeding sources and discrete typing units

Abstract: Background Trypanosoma cruzi is the causative agent of Chagas disease. Due to its genetic diversity has been classified into six Discrete Typing Units (DTUs) in association with transmission cycles. In Colombia, natural T. cruzi infection has been detected in 15 triatomine species. There is scarce information regarding the infection rates, DTUs and feeding preferences of secondary vectors. Therefore, the aim of this study was to determine T. cruzi infection rates, parasite DTU, ecotopes, insect stages, geograp… Show more

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Cited by 56 publications
(89 citation statements)
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“…The field collected individuals were further screened for the presence of Trypanosoma cruzi . The diversity of Trypanosoma cruzi discrete typing units (DTUs), associated with geography, vector species, transmission and clinical outcomes (Hernández et al, 2016 ), spans five out of the six designated DTUs within United States (Garcia et al, 2017 ). Three sets of diagnostic primers were thus employed in this study: one generally amplifying all Trypanosoma cruzi DTUs (TCZ1/TCZ2; Moser et al, 1989 ) and the two other distinguishing for DTUI and the DTUII-VI group (ME/TC1 or TC2; Gumiel et al, 2015 ).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The field collected individuals were further screened for the presence of Trypanosoma cruzi . The diversity of Trypanosoma cruzi discrete typing units (DTUs), associated with geography, vector species, transmission and clinical outcomes (Hernández et al, 2016 ), spans five out of the six designated DTUs within United States (Garcia et al, 2017 ). Three sets of diagnostic primers were thus employed in this study: one generally amplifying all Trypanosoma cruzi DTUs (TCZ1/TCZ2; Moser et al, 1989 ) and the two other distinguishing for DTUI and the DTUII-VI group (ME/TC1 or TC2; Gumiel et al, 2015 ).…”
Section: Methodsmentioning
confidence: 99%
“…Those areas are the hot spots for Chagas disease, with nearly six million people affected (WHO, 2015 ). Among the seven main vector species of Trypanosoma cruzi in Latin America (Hernández et al, 2016 ), the most attention has traditionally been paid to Rhodnius prolixus colonizing domestic habitats (Gourbière et al, 2012 ). For many decades, R. prolixus has also served as a model organism to study insect physiology, immunity, metabolism, and development (Nunes-da-Fonseca et al, 2017 ).…”
Section: Introductionmentioning
confidence: 99%
“…Geographical distribution of R. nasutus and P. lutz is restricted to certain regions of the Northeast region 28 , and both species are considered secondary vectors for T. cruzi transmission. However, research in Colombia has shown the relevance of these species, demonstrating that 59.4% of the secondary vectors had humans as the main food source 29 .…”
Section: Discussionmentioning
confidence: 99%
“…The mapping of vectors (Figure 1) allows the spatial observation of areas with T. cruzi infection and helps the local health services in the control and surveillance of these areas 14 . Geoprocessing techniques have been widely used to understand epidemiological aspects of CD vectors, including characterization of the areas where the disease is present [51][52][53] and the relation between its distribution and reservoirs 29,34 . This reinforces the importance of the data observed in this study.…”
Section: Discussionmentioning
confidence: 99%
“…Estimated CD healthcare costs reach $175,000,000 annually (Castillo-Riquelme et al, 2008). Despite progress in vector control, active transmission by domestic and sylvatic triatomine species is an ongoing threat (Hernández et al, 2016a;Parra-Henao et al, 2016), and several oral outbreaks have occurred (Hernández et al, 2016b;Rueda et al, 2014). Moreover, Colombia confronts various barriers to diagnosis and treatment; only 1.2% of the at-risk population has been screened, while only 0.3-0.4% of expected cases have received etiological treatment (Cucunuba et al, 2017).…”
Section: Introductionmentioning
confidence: 99%