Unsaturated Fatty Acids Improve Atherosclerosis Markers in Obese and Overweight Non-diabetic Elderly Patients

Oliveira, Patrícia Amante de; Kovacs, Cristiane; Moreira, Priscila; Magnoni, Daniel; Saleh, Mohamed Hassan; Faintuch, Joel

doi:10.1007/s11695-017-2704-8

Cited by 41 publications

(42 citation statements)

References 45 publications

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“…Our previous study indicated that vitamins D and K and Ca co-supplementation reduced the maximum levels of left CIMT, yet did not change the mean levels of left and right CIMT in overweight T2DM patients (33) . In another study, the consumption of flaxseed oil for 90 d reduced CIMT in obese and overweight non-diabetic elderly patients (34) . However, vitamin D supplementation for 16 weeks did not change CIMT in patients with metabolic syndrome (35) .…”

Section: Effects On Carotid Intima-media Thicknessmentioning

confidence: 94%

Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

et al. 2019

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This study was performed to evaluate the effects of vitamin D and n-3 fatty acids’ co-supplementation on markers of cardiometabolic risk in diabetic patients with CHD. This randomised, double-blinded, placebo-controlled trial was conducted among sixty-one vitamin D-deficient diabetic patients with CHD. At baseline, the range of serum 25-hydroxyvitamin D levels in study participants was 6·3–19·9 ng/ml. Subjects were randomly assigned into two groups either taking 50 000 IU vitamin D supplements every 2 weeks plus 2× 1000 mg/d n-3 fatty acids from flaxseed oil (n 30) or placebo (n 31) for 6 months. Vitamin D and n-3 fatty acids’ co-supplementation significantly reduced mean (P = 0·01) and maximum levels of left carotid intima–media thickness (CIMT) (P = 0·004), and mean (P = 0·02) and maximum levels of right CIMT (P = 0·003) compared with the placebo. In addition, co-supplementation led to a significant reduction in fasting plasma glucose (β −0·40 mmol/l; 95 % CI −0·77, −0·03; P = 0·03), insulin (β −1·66 μIU/ml; 95 % CI −2·43, −0·89; P < 0·001), insulin resistance (β −0·49; 95 % CI −0·72, −0·25; P < 0·001) and LDL-cholesterol (β −0·21 mmol/l; 95 % CI −0·41, −0·01; P = 0·04), and a significant increase in insulin sensitivity (β +0·008; 95 % CI 0·004, 0·01; P = 0·001) and HDL-cholesterol (β +0·09 mmol/l; 95 % CI 0·01, 0·17; P = 0·02) compared with the placebo. Additionally, high-sensitivity C-reactive protein (β −1·56 mg/l; 95 % CI −2·65, −0·48; P = 0·005) was reduced in the supplemented group compared with the placebo group. Overall, vitamin D and n-3 fatty acids’ co-supplementation had beneficial effects on markers of cardiometabolic risk.

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Section: Effects On Carotid Intima-media Thicknessmentioning

confidence: 94%

Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

et al. 2019

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“…[ 31 ] Subcutaneous fat in the upper body has been proven to be an important source of free fatty acid release in the circulatory system, and especially in obese people. [ 32 , 33 ] The increase in free fatty acid concentration can lead to increased release of inflammatory factors, which can result in insulin resistance and vascular endothelial damage. [ 34 ] Furthermore, neck circumference has good predictive value for the risk of sleep apnea syndrome, [ 35 , 36 ] while sleep apnea syndrome is also closely related to a variety of cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

The correlation between neck circumference and risk factors in patients with hypertension

Zhang¹,

Wu²,

Xu³

et al. 2020

Medicine

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It is necessary to identify the relationship between neck circumference and cardiovascular risk factors in patients with hypertension. Patients with hypertension treated in our hospital were included. The height, weight, neck circumference, waist circumference, fasting blood glucose, 2 h blood glucose (2hPPG), density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and glycated hemoglobin (HbA1c) were analyzed and compared. A total of 2860 patients with hypertension were included. There were significant differences between male and female patients in the neck circumference, waist circumference, fasting blood glucose, Total cholesterol, triacylglycerol, HDL-C, LDL-C, diabetes, metabolic syndrome, dyslipidemia, drinking and smoking (all P < .05); the neck circumference was positively correlated with waist circumference, body mass index (BMI), fasting blood glucose, 2hPPG, HbA1c, triacylglycerol and LDL-C (all P < .05), and negatively correlated with HDL-C (P = .014); as the neck circumference increases, the risk of hypertension, diabetes, metabolic syndrome, abdominal obesity, and dyslipidemia increases accordingly (all P < .05); the area under curve (AUC) was 0.827 and 0.812, and the neck circumference of 37.8 and 33.9 cm was the best cut-off point for male and female patients, respectively. Neck circumference is closely related to cardiovascular risk factors in patients with hypertension, which should be promoted in the screening of cardiovascular diseases.

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“…Oliveira et al 32 verificou que a introdução ou substituição de gorduras saturadas e trans por ácidos graxos insaturados trouxe benefícios para a redução do risco cardiovascular, em idosos obesos ou com excesso de peso e não diabéticos, conferindo, portanto, um fator de proteção.…”

Section: Discussionunclassified

Triagem Nutricional E Riscos Cardiometabólicos Nos Funcionários De Um Restaurante Universitário

Mendes

Carvalho

Justino

et al. 2018

DEMETRA

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Nutritional screening and cardiometabolic risks in the workers of a University RestaurantResumo Introdução: Os riscos cardiometabólicos são caracterizados por um conjunto de disfunções no metabolismo que predispõem a eventos cardiovasculares, quando coexistem no organismo. Objetivo: realizar triagem nutricional e investigar fatores de riscos cardiometabólicos em funcionários de um Restaurante Universitário. Método: foi realizada uma coleta de informações de 18 funcionários, por meio de uma ficha de atendimento e os dados obtidos foram analisados através do software DietBox e tabelados pelo programa Microsoft Office Excel. Resultados: Dentre os participantes 33% apresentaram sobrepeso e maior risco para desenvolvimento de doenças crônicas não transmissíveis, sendo que os homens apresentaram maior porcentagem de perímetro abdominal (42,8%). Além disso, foi possível notar que 33,3% das pessoas estudadas apresentaram valores de HDL-c baixo e 27,7% colesterol total aumentado. Em média, observaram-se variações do consumo diário de calorias em relação às recomendações de 38,8% para mais e 55,5% para menos. Em relação aos inquéritos alimentares, dentre os macronutrientes, destacou-se maior ingestão proteica e, dentre os micronutrientes, o sódio e selênio foram consumidos acima do recomendado e as fibras, enquanto cálcio e vitaminas D e E foram consumidos abaixo da recomendação. Conclusão: O estudo demonstrou a presença de fatores que predispõem a eventos cardiovasculares na população. Os aumentados índices de sobrepeso e obesidade nos indivíduos analisados foram possivelmente devidos a alterações dos padrões alimentares e reduzida da prática de atividade física.Palavras-chave: Doenças Cardiovasculares. Dislipidemias. Sobrepeso. Deficiências Nutricionais. AbstractIntroduction: Cardiometabolic risks are characterized by a set of metabolic dysfunctions that predispose to cardiovascular events, when they coexist in the body. Objective: The purposes of this study are to perform the nutritional assessment and to investigate the cardiometabolic risk factors in the employees of a University Restaurant. Method: There have been collected socioeconomic, individual, anthropometric, alimentary data and biochemical exams (lipid profile and fasting glycemia) from eighteen employees through a data sheet and the data obtained were analyzed by the DietBox software. Results: Among the participants, 33% were overweight and had higher risk of developing chronic noncommunicable diseases, where men presented higher percentage of abdominal circumference (42.8%). Furthermore, it was possible to notice that 33.3% of the employees presented low HDL-C values and 27.7% increased total cholesterol. On average, daily calorie consumption variations were observed in relation to the recommendations of around 38.8% for more and 55.5% for less. Regarding feeding habit surveys, higher protein intake was observed and, among the macronutrients, it was noticed that the general daily intake values were according to the recommendations. Cholesterol, trans fat, s...

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Unsaturated Fatty Acids Improve Atherosclerosis Markers in Obese and Overweight Non-diabetic Elderly Patients

Cited by 41 publications

References 45 publications

Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

The correlation between neck circumference and risk factors in patients with hypertension

Triagem Nutricional E Riscos Cardiometabólicos Nos Funcionários De Um Restaurante Universitário

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