Unresolved Issues in Longitudinal Telomere Length Research: Response to Susser et al.

Verhoeven, Josine E.; Lin, Jue; Révész, Dóra; Wolkowitz, Owen M.; Penninx, Brenda W. J. H.

doi:10.1176/appi.ajp.2016.16060747r

Cited by 5 publications

(2 citation statements)

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“…Previously published studies, based upon cross-sectional data, 4,16 have demonstrated an "oscillating" nature of intraindividual TL changes and suggested that TL elongation over a short period of time may represent measurement variation or error due to nonlinear TL changes as opposed to the general trend of attrition over longer periods of follow-up. [23][24][25] We observed intra-individual TL variation over time in the study DC patients, but the overall trend with longer follow-up was for shortening in both androgen-treated and untreated patients (Figure 1).…”

Section: 40mentioning

confidence: 86%

Similar telomere attrition rates in androgen-treated and untreated patients with dyskeratosis congenita

et al. 2018

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Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome and the prototypic telomere biology disorder (TBD). Leukocyte telomere length (TL) less than the first percentile for age, measured by flow cytometry with in situ hybridization (flow FISH), is diagnostic of DC. Androgens are a therapeutic option for DC/TBD-associated bone marrow failure (BMF). One report has shown an apparent increase in TL in patients while on treatment with the attenuated androgen danazol. The aim of this study was to compare TL over time in 10 androgen-treated and 16 untreated patients with DC. All subjects were enrolled in institutional review board-approved longitudinal cohort studies of inherited BMF. TL in 6-panel leukocyte subsets was measured by flow FISH. Generalized estimating equations (GEE) methodology was used to compare TL changes over time between groups. Unadjusted analyses showed annual median total lymphocyte TL attrition of -62 base pairs/year (bp/y) in androgen-treated patients with DC compared with -76 bp/y in untreated DC patients ( = .71). Longitudinal analysis using a GEE model, adjusted for age at sample collection, showed no statistically significant difference in TL change over time between treated and untreated patients ( = .24). The results were similar for each individual leukocyte subset evaluated. In summary, our data show the expected age-associated longitudinal telomere shortening in patients with DC, irrespective of androgen therapy. Caution is warranted when recommending androgen therapy for non-BMF manifestations of DC or TBDs until the biological mechanisms are better understood.

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Section: 40mentioning

confidence: 86%

Similar telomere attrition rates in androgen-treated and untreated patients with dyskeratosis congenita

et al. 2018

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“…Some studies demonstrate that telomere length is dynamic, with the possibility of lengthening over time, though there is wide debate in the literature about whether telomeres can actually lengthen over time. [76][77][78] In the CARDIA study, whole blood samples were collected with the same protocols and the same type of genomic DNA extraction kit was used to extract DNA, but different lots were used in both procedures. Telomere length assays for Y15 and Y20 DNA were completed at the same time, with Y15 and Y20 samples from the same individual on the same plate, circumventing major criticisms suggesting serious measurement errors when telomere lengths are assayed at different times and on different plates.…”

Section: Discussionmentioning

confidence: 99%

Chronic psychosocial and financial burden accelerates 5-year telomere shortening: findings from the Coronary Artery Risk Development in Young Adults Study

et al. 2019

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Leukocyte telomere length, a marker of immune system function, is sensitive to exposures such as psychosocial stressors and health-maintaining behaviors. Past research has determined that stress experienced in adulthood is associated with shorter telomere length, but is limited to mostly crosssectional reports. We test whether repeated reports of chronic psychosocial and financial burden is associated with telomere length change over a 5-year period (Years 15 and 20) from 969 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study, a longitudinal, population-based cohort, ages 18-30 at time of recruitment in 1985. We further examine whether multisystem resiliency, comprised of social connections, health-maintaining behaviors, and psychological resources, mitigates the effects of burden on telomere attrition over five years. Our results indicate that adults with high chronic burden do not show decreased telomere length over the five-year period. However, these effects do vary by level of resiliency, as regression results revealed a significant interaction between chronic burden and multisystem resiliency. For individuals with high chronic burden and low multisystem resiliency (1SD below the mean), there was a significant 5-year shortening in telomere length, whereas no significant relationships between chronic burden and attrition were evident for those at moderate and higher levels of resiliency. These effects apply similarly across the three components of resiliency. Results imply that interventions should focus on establishing strong social connections, Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:

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Delayed sleep-onset and biological age: late sleep-onset is associated with shorter telomere length

Wynchank¹,

Bijlenga²,

Penninx

et al. 2019

Sleep

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Study Objectives We evaluated the relationship between leukocyte telomere length (LTL) and sleep duration, insomnia symptoms, and circadian rhythm, to test whether sleep and chronobiological dysregulations are associated with cellular aging. Methods Data from the Netherlands Study of Depression and Anxiety (N = 2,936) were used at two waves 6 years apart, to measure LTL. Telomeres shorten during the life span and are important biomarkers for cellular aging. LTL was assessed by qualitative polymerase chain reaction and converted into base pair number. Sleep parameters were: sleep duration and insomnia symptoms from the Insomnia Rating Scale. Circadian rhythm variables were: indication of Delayed Sleep Phase Syndrome (DSPS), mid-sleep corrected for sleep debt on free days (MSFsc), sleep-onset time, and self-reported chronotype, from the Munich Chronotype Questionnaire. Generalized estimating equations analyzed the associations between LTL, sleep, and chronobiological factors, adjusted for baseline age, sex, North European ancestry, and additionally for current smoking, depression severity, obesity, and childhood trauma. Results Indicators of delayed circadian rhythm showed a strong and consistent effect on LTL, after adjustment for sociodemographic and health indicators. Late MSFsc (B = −49.9, p = .004), late sleep-onset time (B = −32.4, p = .001), indication of DSPS (B = −73.8, p = .036), and moderately late chronotype in adulthood (B = −71.6, p = .003) were associated with significantly shorter LTL across both waves; whereas sleep duration and insomnia symptoms were not. Extremely early chronotype showed significantly less LTL shortening than intermediate chronotype (B = 161.40, p = .037). No predictors showed accelerated LTL attrition over 6 years. Conclusions Individuals with delayed circadian rhythm have significantly shorter LTL, but not faster LTL attrition rates.

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Unresolved Issues in Longitudinal Telomere Length Research: Response to Susser et al.

Cited by 5 publications

References 1 publication

Similar telomere attrition rates in androgen-treated and untreated patients with dyskeratosis congenita

Similar telomere attrition rates in androgen-treated and untreated patients with dyskeratosis congenita

Chronic psychosocial and financial burden accelerates 5-year telomere shortening: findings from the Coronary Artery Risk Development in Young Adults Study

Delayed sleep-onset and biological age: late sleep-onset is associated with shorter telomere length

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