Unrecognized oral manifestations of Langerhans cell histiocytosis which progressed to systemic disease

Alajbeg, Ivan; Boras, Vanja Vučičević; Femenić, Ranka; Cekić-Arambašin, Ana; Aničić, Mirna; Kelečić, Jadranka; Alajbeg, Iva

doi:10.1016/j.ooe.2005.07.012

Cited by 12 publications

(12 citation statements)

References 10 publications

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“…Namely, some recent studies of nonaromatic naphthalane (NAN), which is a noncolored transparent version of naphthalane, stressed the potential significance of steranes as the healing components in the related analytical [11][12][13], biomedical [14], and clinical [15] research. Since aromatic compounds are the expected constituents of brown naphthalanes, and since there are aromatics which should be taken with caution due to their potential carcinogenity, aromatics were studied for ring number and quantity.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Azerbaijani and Croatian brown naphthalane

Alajbeg¹,

Donelli²,

Alajbeg³

et al. 2005

J of Separation Science

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In spite of the fact that noncolored (nonaromatic) naphthalane containing high sterane content has been proved as bioactive and efficient in the treatment of psoriasis vulgaris, brown naphthalanes, which contain aromatics, are still in use. Thousands of patients, who have been passing through the therapy, deserve thorough and permanent study of brown naphthalanes. For that reason, two frequently used brown naphthalane preparations, one of the Azerbaijani (N1) and the other of the Croatian (N2) origin, were studied. The samples underwent the study by means of GC, OT LC, and normal-phase HPLC, as separation techniques. In addition, some bulk properties, elemental composition, and group composition by 1H NMR were determined. GC-MS served in compound types, especially in sterane detection. Both of the samples were found to be unresolved complex mixtures, relatively poor in n-alkanes. Isoalkanes, cycloalkanes, and aromatic compounds, in a great variety of isomers and homologs, made the majority of both of the samples. N1 was a dark, viscous, nontransparent fluid with a strong petroleum smell. Aromatics, which made 53% mass by OT LC and 54% mass by 1H NMR were found to be composed of mono-, di-, and tri+ -aromatic compounds. Tri+ -aromatic compounds were three to four times more abundant in N1 than in N2. Beside hydrocarbons, N1 comprised some organic compounds with polar functional groups. Also, some asphaltenes were found in it. N1 contained well-presented steranes, which are thought to be bioactive naphthalane ingredients. N2 was a pale brown liquid, with smell similar to gasoline. It contained somewhat lower percentage of aromatics (46% mass) and comparatively lower percentage of tri+ fused aromatics among which carcinogens might be expected. N2 was almost purely composed of hydrocarbons. It seemed to contain low content of steranes due to relatively low upper temperature of the distillation range applied in N2 preparation.

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Section: Introductionmentioning

confidence: 99%

Characterization of Azerbaijani and Croatian brown naphthalane

Alajbeg¹,

Donelli²,

Alajbeg³

et al. 2005

J of Separation Science

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“…Particularly in the posterior mandible of the jaw, distal to the canine. 14,15 In this case, the posterior mandible had been affected.…”

Section: Discussionmentioning

confidence: 83%

Rare Langerhans cell histiocytosis in children: a case report

Fadil

Almajid

2019

Int J Res Med Sci

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Langerhans cell histiocytosis (LCH) is a rare disease, formally known as histiocytosis X that is characterized by abnormal proliferation of histiocytes derived from bone marrow (Langerhans cells), joined with leucocytes, eosinophils, neutrophils, lymphocytes, plasma cells and giant multi-nucleated cells causing tissue destruction. One of the first signs of LCH is oral manifestation, in some cases, the oral cavity may be the only affected area. With the chance of oral lesion incidence in LCH being 77%.Initial symptoms are generally nonspecific, which can easily cause misdiagnoses.The purpose of reporting this case is to discuss the features of LCH clinically and radiographically and in the role of the dentist when diagnosing such lesions for a proper management.An 11-year-old boy reported a complaint of swelling in the left side of the lower jaw that is asymptomatic and had been gradually increasing in size for the past 6 months without any improvements. After preforming a biopsy and diagnosing the lesion as LCH, the patient was then treated with a dose of vinblastine (6 mg/m2 intravenous bolus) for 24 weeks as a total period. Two years follow up; the patient showed no sign of recurrence and is in good general condition. In conclusion, reporting this case serves as documentation of the proper route of clinical assessment and diagnosis of LCH with the best possible treatment as guidance.

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“…Namely, some earlier studies indicated the structural similarity of geogenic steranes to bioactive natural and synthetic steroids (vitamins, steroid hormones, drugs and other steroid compounds). 9 For example, ergostane was found to be the structural analog of vitamin D 2 and cholestane to be the structural analog of vitamin D 3 . 9 In Table 5 there are the data -on original Azerbaijani Naphthalan which is a rather viscous dark preparation, containing 53% of aromatic compounds, including 19% of tri+ aromatics; 12 -on Brown Naphthalan, used in Special Hospital Naftalan for years, until recently, with significantly diminished heavy aromatics (compared to Azerbaijani Naphthalan), but also with diminished sterane concentration; 8 -on White Naphthalan, which was experimentally produced with no aromatics, but denatured: with sterane moieties destroyed and bioactivity lost; 5 -on NAVS Naphthalan which provided the best composition with very high content of steranes and no aromatics which was clinically tested and showed healing effects on psoriatic skin; 8 unfortunately, the sophisticated and expensive preparation processes delayed its production; -on Yellow Naphthalan which recently substituted Brown Naphthalan; it has improved sterane concentration and lowered aromatics concentration; -on PY Naphthalan as a rather improved version regarding sterane content and regarding a remarkable decrease of aromatic content; sterane concentration in PY Naphthalan is roughly estimated to be twice as high as in original Azerbaijani Naphthalan, six times higher than in Brown Naphthalan and higher than in Yellow Naphthalan.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8][9][10][11][12] On the one hand, molecular skeletons of some potentially bioactive geogenic steranes were similar to D-vitamins, steroid hormones and corticosteroid drugs. 9 On the other hand, the research emphasized the problem associated with the presence of toxic polycyclic aromatic hydrocarbons (PAHs) which are common constituents of naphthalan oils 13,14 as well as of non-refined naphthalan preparations. 12 Following recommendations from the previous research, an improved naphthalan version, called Pale Yellow (PY) Naphthalan, has been developed.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Physical Properties of “Pale Yellow” Naphtalan

Alajbeg¹,

Brkić²,

Ahel³

et al. 2011

Croat. Chem. Acta

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Abstract. The Pale Yellow (PY) Naphthalan is potentially a new treatment modality for some oral mucosal and dermatological diseases. Its chemical composition and physical properties were studied by standard and sophisticated methods. Special attention was paid to steranes and hopanes as favorable components and to aromatics as unfavorable compounds. PY Naphthalan is predominantly composed of saturated aliphatic hydrocarbons of different structures, and of hydrocarbons comprising aromatic ring(s) (< 15%). Among aromatics, 98% were monoaromatics and 2% diaromatics, while 16 polycyclic aromatic hydrocarbons designated by US Environmental Protection Agency as priority pollutants were found at minimum detectability levels. Steranes and hopanes appeared in native geogenic clusters of homologs and each of identified compounds was in native geogenic configuration. Steranes were in the range from norcholestanes up to propyl cholestanes and hopanes up to pentakishomohopanes. The content of steranes and hopanes was relatively high. Compared to the other naphthalan products, the composition of PY Naphthalan is remarkably improved. Physical properties make PY Naphthalan convenient for application. (doi: 10.5562/cca1886)

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Unrecognized oral manifestations of Langerhans cell histiocytosis which progressed to systemic disease

Cited by 12 publications

References 10 publications

Characterization of Azerbaijani and Croatian brown naphthalane

Characterization of Azerbaijani and Croatian brown naphthalane

Rare Langerhans cell histiocytosis in children: a case report

Chemical Composition and Physical Properties of “Pale Yellow” Naphtalan

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