Unravelling the role of EMT in OSCC: A quick peek into HPV-mediated pathogenesis

Saraf, Shantanu; Suresh, P.K.; Das, Raunak Kumar

doi:10.1016/j.oor.2023.100016

Cited by 1 publication

(1 citation statement)

References 89 publications

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“…EMT is an essential step for the development of invasive cells and metastasis, and it is controlled by the transcription factors twist family bHLH transcription factor 1 (TWIST1) and snail family transcriptional repressors 1 (SNAI1) and 2 (SNAI2). The stimulation of the EMT enhances metastasis, tumor cell invasion, and treatment resistance since it is a rich source of CSCs [ 46 , 47 ].…”

Section: Viral Infection Promotes Cancer Stem Cells In Different Cancersmentioning

confidence: 99%

The role of oncolytic virotherapy and viral oncogenes in the cancer stem cells: a review of virus in cancer stem cells

Faghihkhorasani,

Dalvand,

Derafsh

et al. 2023

Cancer Cell Int

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Cancer Stem Cells (CSCs) are the main “seeds” for the initiation, growth, metastasis, and recurrence of tumors. According to many studies, several viral infections, including the human papillomaviruses, hepatitis B virus, Epstein–Barr virus, and hepatitis C virus, promote the aggressiveness of cancer by encouraging the development of CSC features. Therefore, a better method for the targeted elimination of CSCs and knowledge of their regulatory mechanisms in human carcinogenesis may lead to the development of a future tool for the management and treatment of cancer. Oncolytic viruses (OVs), which include the herpes virus, adenovirus, vaccinia, and reovirus, are also a new class of cancer therapeutics that have favorable properties such as selective replication in tumor cells, delivery of numerous eukaryotic transgene payloads, induction of immunogenic cell death and promotion of antitumor immunity, as well as a tolerable safety profile that essentially differs from that of other cancer therapeutics. The effects of viral infection on the development of CSCs and the suppression of CSCs by OV therapy were examined in this paper. The purpose of this review is to investigate the dual role of viruses in CSCs (oncolytic virotherapy and viral oncogenes). Graphical Abstract

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Section: Viral Infection Promotes Cancer Stem Cells In Different Cancersmentioning

confidence: 99%

The role of oncolytic virotherapy and viral oncogenes in the cancer stem cells: a review of virus in cancer stem cells

Faghihkhorasani,

Dalvand,

Derafsh

et al. 2023

Cancer Cell Int

View full text Add to dashboard Cite

show abstract

Unravelling the role of EMT in OSCC: A quick peek into HPV-mediated pathogenesis

Cited by 1 publication

References 89 publications

The role of oncolytic virotherapy and viral oncogenes in the cancer stem cells: a review of virus in cancer stem cells

The role of oncolytic virotherapy and viral oncogenes in the cancer stem cells: a review of virus in cancer stem cells

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