Unraveling the Mystery of Auditory Brainstem Response Corrections: The Need for Universal Standards

Norrix, Linda W.; Velenovsky, David S.

doi:10.3766/jaaa.16112

Cited by 8 publications

(6 citation statements)

References 32 publications

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“…To ensure the alignment between behavioral and electrophysiological methods, it is common to apply a correction factor that translates the thresholds of one system to another system. However, as of this time, there is not a single universal correction factor, and such factor differs based on the method or the system (Norrix & Velenovsky, 2017; Ghasemahmad & Farahani, 2019; Yeung & Wong, 2007; McCreery et al, 2015). To enable the translation between EEG and PTA thresholds, an additional study is required to uncover a correction factor to address this perceptual difference between long and short pure-tone.…”

Section: Discussionmentioning

confidence: 99%

Fast and robust objective EEG audiometry

Guyonnet-Hencke,

Portoles,

de Vries

et al. 2024

Preprint

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The current ‘gold standard’ of audiometry relies on subjective behavioral responses, which is impractical and unreliable for certain groups such as children, individuals with severe disabilities, or the disabled elderly. This study presents a novel electroencephalography (EEG) system that is easy to setup and estimates audiometric thresholds quickly. Air-conduction audiometric thresholds at 250, 500, 1000, 2000, 4000, and 8000 Hz and 5 dB resolution were estimated from ten elderly patients with asymmetric sensorineural hearing loss and five normal hearing young adults using three different systems: the novel EEG system, conventional pure-tone audiometry (PTA), and an automated behavioral test with the same stimulus properties as in the EEG test. EEG data was collected for 15 minutes from 32 semi-dry EEG electrodes. Later, the EEG system was trimmed to 8 electrodes and 7.5 minutes of data with satisfactory results. Correlation and regression analysis validated the hearing thresholds derived from both EEG configurations relative to the behavioral hearing thresholds–Pearson’s correlation of 0.82 between PTA and 8-electrode 7.5-minute EEG data. The results of this study open the door to fast and objective hearing threshold estimation with EEG.

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Section: Discussionmentioning

confidence: 99%

Fast and robust objective EEG audiometry

Guyonnet-Hencke,

Portoles,

de Vries

et al. 2024

Preprint

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“…It is important to note that use of ±2 standard deviations represents 95.5% of the population, and this should result in only a small number of inappropriate diagnoses. The ABR assessment is one of several clinical tests used by healthcare professionals to test for the presence of hearing loss [ 13 , 14 ]. Neurodiagnostics aims to detect retrocochlear pathologies present in the auditory nervous system that impair proper functioning of anatomical structures such as the proximal and distal portions of the auditory nerve, cochlear nuclei, superior olivary nuclei, lateral lemnisci, and inferior colliculi [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Latency and Interpeak Interval Values of Auditory Brainstem Response in 73 Individuals with Normal Hearing

et al. 2022

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Background Auditory brainstem response (ABR) potential is important for audiological diagnosis, reflecting the integrity of the structures of the auditory system up to the brainstem. The click stimulus is the best known and is most used in clinical practice. However, different devices and examiners may yield distinct results, and each institution tends to use its own parameters. We aimed to analyze the latency values of wave I, III, V, and interpeak intervals I–III, III–V, I–V values obtained in assessing ABR using a new device. Material/Methods We performed a cross-sectional study of 73 participants with normal hearing thresholds and no hearing problems. All underwent basic audiological (air and bone conduction, Speech Recognition Threshold, Speech Recognition Index, acoustic reflex, and tympanometry) and electrophysiological evaluation (ABR assessment). Results Absolute latency and interpeak values from ABR showed earlier responses in women, faster than international standards suggest. The responses were similar to other studies carried out previously, with the exception of wave I values, which were a little earlier in females. Conclusions We assessed normative data from measurement of latency values of wave I, III, V, and interpeak intervals I–III, III–V, and I–V applying 2 standard deviations in the assessment of ABR using the new Neuro-Audio/ABR device created by Neurosoft.

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“…We used SOD measurements as a tool to evaluate the effects of rutin on auditory neuropathy in diabetic rats. The restoration of SOD levels after neuropathy treatment has been investigated in many studies [ 15 , 16 , 18 ]. Our results also indicate that rutin ameliorates auditory neuropathy by normalizing SOD.…”

Section: Discussionmentioning

confidence: 99%

“…The reduction of MDA levels by rutin treatment furnishes evidence in support of this novel treatment for diabetic auditory neuropathy. MDA levels have been evaluated as an oxidative marker in some experimental and clinical trials of antioxidant agents, with relatively successful results [ 15 , 16 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…The electrical activity recorded after stimulation includes a series of five to seven vertexpositive waves, each of which is considered to correspond to a specific site in the auditory pathway. Although the localization is not fully clear, it is believed that waves I, II, III, IV, and V correlate with the activity of the auditory nerve, cochlear nucleus, superior olivary complex, lateral lemniscus, and inferior colliculus, respectively [ 7 , 17 , 18 ]. DM has been shown to affect the microvasculature of the cochlea, and the resultant ischemia causes morphological changes in the stria vascularis, sensory cells, and spiral ganglion [ 6 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model

Doostkam

Mirkhani

Iravani

et al. 2021

Clin Exp Otorhinolaryngol

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Objectives. Diabetic auditory neuropathy is a common complication of diabetes mellitus that has a major impact on patients' quality of life. In this study, we assessed the efficacy of rutin in treating diabetic auditory neuropathy in an experimental rat model. Methods. Forty Sprague-Dawley rats were randomly assigned to the following groups: group 1, control; group 2, diabetic rats; and groups 3-5, rats treated with rutin (at doses of 50, 100, and 150 mg/kg, respectively). We used auditory brain stem response, stereology of the spiral ganglion, and measurements of superoxide dismutase (SOD) and malondialdehyde (MDA) to evaluate the effects of treatment. Results. Significant improvements in auditory neuropathy were observed in the rutin-treated groups in comparison with the diabetic group (P<0.05). Auditory threshold, wave latency, wave morphology, the volume and number of neurons in the spiral ganglion, and SOD and MDA activity showed improvements following treatment. Conclusion. Rutin shows promise as a treatment modality for diabetic auditory neuropathy, but more trials are warranted for its clinical application.

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Unraveling the Mystery of Auditory Brainstem Response Corrections: The Need for Universal Standards

Abstract: Toneburst ABR thresholds do not perfectly align with behavioral hearing thresholds. Universal protocols for the use of corrections are needed. Additionally, evidence-based procedures must be employed to obtain valid ABRs that will accurately estimate hearing thresholds.

Cited by 8 publications

References 32 publications

Fast and robust objective EEG audiometry

Fast and robust objective EEG audiometry

Latency and Interpeak Interval Values of Auditory Brainstem Response in 73 Individuals with Normal Hearing

Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model

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