Unraveling the Expression Profiles of Long Noncoding RNAs in Rat Cardiac Hypertrophy and Functions of lncRNA BC088254 in Cardiac Hypertrophy Induced by Transverse Aortic Constriction

Li, Xiaoying; Zhang, Lei; Liang, Jiangjiu

doi:10.1159/000443370

Cited by 19 publications

(17 citation statements)

References 29 publications

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“…As an important shuttle protein between the mitochondria and nuclei, PHB was found to have a potential protective role against the development of hypertrophy. 17,[36][37][38][39] In our present study, ARC could interact with PHB in the nucleus and participate in maintaining the level of PHB in cells. However, our data just implicated the correlation between PHB and nuclear ARC, and further studies would be necessary to explore whether PHB is required in the anti-hypertrophic role of ARC.…”

Section: Discussionsupporting

confidence: 52%

“…In fact, compared with its role in the cytoplasm, very little has been published regarding the molecular function of nuclear ARC. 17,[36][37][38][39] In our present study, ARC could interact with PHB in the nucleus and participate in maintaining the level of PHB in cells. [31][32][33] Nevertheless, the physiological functions of nuclear ARC are still unknown.…”

Section: Discussionmentioning

confidence: 63%

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Loss of nuclear ARC contributes to the development of cardiac hypertrophy in rats

et al. 2019

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Aim: Cardiac hypertrophy and myocardial apoptosis are two major factors in heart failure. As a classical regulator of apoptosis, apoptosis repressor with caspase recruitment domain (ARC) has recently also been found to have a protective effect against hypertrophy. However, the mechanism underlying this effect is still not fully understood. Methods: In the present study, we established animal and cellular models to monitor the changes in total and nuclear ARC during cardiac hypertrophic processes. The preventive effects of nuclear ARC in cellular hypertrophy were verified by ARC regulation and nuclear export inhibition. To further explore the mechanism for nuclear ARC superficially, we analysed proteins that interact with ARC in the nucleus via Co-IP and mass spectrometry. Results: The expression of total ARC in hypertrophic myocardial tissue and H9C2 cells remained invariant, while the level of nuclear ARC decreased dramatically. By altering the content of ARC in H9C2 cells, we found that both nuclear ARC transfection and nuclear ARC export blockade attenuated norepinephrine or angiotensin II-induced hypertrophy, while ARC knockdown had an inverse effect. Co-IP data showed that ARC interacted with prohibitin (PHB) in the nucleus and might participate in maintaining the level of PHB in cells. Conclusions: These findings suggest a novel mechanism for ARC in cardiac hypertrophy prevention and also indicate that the anti-hypertrophic roles of ARC are probably associated with its localization in nucleus, which imply the nuclear ARC as a potential therapeutic target for cardiac hypertrophy. K E Y W O R D SARC, cardiac hypertrophy, hypertension, norepinephrine, nuclear localization

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 63%

Loss of nuclear ARC contributes to the development of cardiac hypertrophy in rats

et al. 2019

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“…Bioinformatics and coexpression network analyses suggest that lncRNA BC088254 has a relationship with phb2 and can weakly affect the expression of phb2, but the result still needs to be verified [78]. Two lncRNAs named MI-associated transcript 1 (MIRT1) and 2 (MIRT2) are revealed to be significantly increased in MI mice and relevant to multiple genes known to be involved in cardiac remodeling, such as Icam1 , Tgfb1 , etc.…”

Section: Lncrnas and Cardiac Remodelingmentioning

confidence: 99%

The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling

Gao

Wang

et al. 2017

IJMS

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Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins. Studies show that ncRNAs are not only involved in cell proliferation, apoptosis, differentiation, metabolism and other physiological processes, but also involved in the pathogenesis of diseases. Cardiac remodeling is the main pathological basis of a variety of cardiovascular diseases. Many studies have shown that the occurrence and development of cardiac remodeling are closely related with the regulation of ncRNAs. Recent research of ncRNAs in heart disease has achieved rapid development. Thus, we summarize here the latest research progress and mainly the molecular mechanism of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), in cardiac remodeling, aiming to look for new targets for heart disease treatment.

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“…So, it is unquestionable that lncRNAs have clinical importance in colon cancer biology and prognosis. 14 …”

Section: Biological Functions Of Lncrnasmentioning

confidence: 99%

Long non-coding RNAs: New biomarkers for prognosis and diagnosis of colon cancer

Deng

Wang

et al. 2017

Tumour Biol.

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BackgroundColorectal cancer (CRC) is the third most diagnosed cancer in this blue planet, whose incidence is increasing in young adults, especially in the developing countries. 1 As the fourth main cause of cancer-related deaths in the world, CRC contributes to a serious threat to human health. To descend mortality of CRC, in past decades, researchers strive to study the mechanisms of this disease. Unfortunately, the prognosis of this malignancy remains pessimistic in numerous patients who even received surgery, and the cancer reappear or metastasis come up after several months. One of the leading challenges of this disease is the clinical diagnosis may be late. 2 Therefore, biological biomarkers for the identification of detection and prediction may have clinical significance. Especially, in past decade, extensive molecular research has demonstrated that long non-coding RNAs (lncRNAs) may be novel and significant biological biomarkers for early diagnosis and prognosis of colon cancer. 3 As its name indicates, LncRNAs are a group of noncoding RNA molecules whose lengths are larger than 200 nucleotides and lack protein-coding capability.

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Unraveling the Expression Profiles of Long Noncoding RNAs in Rat Cardiac Hypertrophy and Functions of lncRNA BC088254 in Cardiac Hypertrophy Induced by Transverse Aortic Constriction

Cited by 19 publications

References 29 publications

Loss of nuclear ARC contributes to the development of cardiac hypertrophy in rats

Loss of nuclear ARC contributes to the development of cardiac hypertrophy in rats

The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling

Long non-coding RNAs: New biomarkers for prognosis and diagnosis of colon cancer

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