“…Croutch et al [102] administered TCDD and HxCDD to rats and measured the levels of circulating insulin, glucose, and IGF-I, as well as hepatic levels of phos-phoenolpyruvate carboxykinase (PEPCK) mRNA expression, and found that both TCDD and HxCDD inhibit IGF-I, with less inhibition of PEPCK, and attributed the weight loss seen in the animals to these actions, but no changes in levels of either insulin or glucose were observed. Johnson et al [103] reported a genes' network showing interactions between the AhR, cytochrome P450 1B1, IGF-binding protein-5 (IGFBP-5), lysyl oxidase, and osteopontin [59]. Some studies have focused on specific genes.…”