Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm

Illouz, Tomer; Madar, Ravit; Louzon, Yoram; Griffioen, Kathleen J.; Okun, Eitan

doi:10.1016/j.bbi.2015.10.013

Cited by 47 publications

(50 citation statements)

References 29 publications

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“…Starch was mixed in water to make it opaque. Rats were trained individually, before start of study, to reach submerged platform [22]. Time to reach the platform was noted for each rat at interval of 15 days for two months.…”

Section: Water Maze Testmentioning

confidence: 99%

Antidepressant and Antiamnesic Potential of Foeniculum vulgare

Abbas

Ikram

Hasan

et al. 2020

JAMMR

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Aim:To evaluate the antiamnesic and antidepressant effect of Foeniculum vulgare whole crushed seeds. Study Design: Laboratory based randomized control study. Place and Duration of Study: Methodology: Thirty swiss albino mice and wistar rats were divided equally in three groups. Control group was fed on standard rodent diet, group 2 was fed on 2% Foeniculum vulgare diet and group 3 was given 4% Foeniculum vulgare diet. Antidepressant activity was assessed using forced swimming test. Memory enhancement effect was evaluated by stationary rod test, passive avoidance test and water maze test. Abbas et al.; JAMMR, 32(1): 131-138, 2020; Article no.JAMMR.54564 132 Results: Increased duration of struggling time was noted in both group 2 and group 3 as compared to control in forced swimming test. Decrease in time to reach platform in both water maze and stationary rod test was recorded in both the study group (group 2 & 3). Increase in step through latency was also seen in group 2 and group 3 as compared to control group. Conclusion: The results showed the memory enhancing and antidepressant actions of Foeniculum. Original Research Article

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Section: Water Maze Testmentioning

confidence: 99%

Antidepressant and Antiamnesic Potential of Foeniculum vulgare

Abbas

Ikram

Hasan

et al. 2020

JAMMR

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“…While control mice were able to learn the task as indicated by a reduced escape latency throughout the 10 days of training, Setd1b cKO mice were severely impaired ( Fig 1F). We also performed a more sensitive analysis using a modified version of the MUST-C algorithm to measure the different spatial strategies that represent either hippocampus-dependent or independent abilities (Illouz et al, 2016). Our results indicate that Setd1b cKO mice fail to adapt hippocampus-dependent search strategies such as "direct", "corrected" and "short-chaining" (Fig 1G).…”

Section: Loss Of Setd1b In Adult Forebrain Neurons Impairs Hippocampumentioning

confidence: 91%

“…The behavioral experiments were performed as described previously (Kerimoglu et al, 2017b). For in depth feature analysis from water maze data, a modified version of MUST-C algorithm was used (Illouz et al, 2016).…”

Section: Behavior Experimentsmentioning

confidence: 99%

SETD1B controls cognitive function via cell type specific regulation of neuronal identity genes

Michurina

Sakib

Kerimoğlu

et al. 2020

Preprint

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Histone-3-lysine-4-methylation (H3K4me) is mediated by six different lysine methyltransferases (KMTs). Amongst these enzymes SET domain containing 1b (SETD1B) has been linked to intellectual disability but its role in the adult brain has not been studied yet. Here we show that mice lacking Setd1b from excitatory neurons of the adult forebrain exhibit severe memory impairment. By combining neuron-specific ChIP-seq, RNA-seq and single cell RNA-seq approaches we show that Setd1b controls the expression of neuronal-identity genes with a broad H3K4me3 peak linked to learning and memory processes. Our data furthermore suggest that basal neuronal gene-expression is ensured by other H3K4 KMTs such as Kmt2a and Kmt2b while the additional presence of Setd1b at the single cell level provides transcriptional consistency to the expression of genes important for learning & memory.

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“…Using previous rodent based methods developed for Morris water maze (Wolfer & Lipp, 2000;Graziano et al, 2003;Gehring et al, 2015;Illouz et al, 2016;Vouros et al, 2018), we quantified four different features from the swimming trajectories of zebrafish. Coordinates of the swimming trajectories were extracted from the Viewpoint-…”

Section: Automated Locomotion Analysismentioning

confidence: 99%

Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish

Chhabria

Vouros

Gray

et al. 2019

Preprint

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Diabetes is associated with dysfunction of the neurovascular unit, although the mechanisms of this are incompletely understood, and currently no treatment exists to prevent these negative effects. We previously found that the NO donor sodium nitroprusside (SNP) prevents the detrimental effect of glucose on neurovascular coupling in zebrafish. We therefore sought to establish the wider effects of glucose exposure on both the neurovascular unit and on behaviour in zebrafish and the ability of SNP to prevent these.We incubated 4 days post fertilisation (dpf) zebrafish embryos in 20mM glucose or mannitol for five days until 9dpf, with or without 0.1mM SNP co-treatment for 24h (8-9dpf), and quantified vascular nitric oxide reactivity, vascular mural cell number, expression of a klf2a reporter, glial fibrillary acidic protein (GFAP) and TRPV4, as well as spontaneous neuronal activation at 9dpf, all in the optic tectum. We also assessed the effect on light/dark preference and locomotory characteristics during free-swimming studies.We find that glucose exposure significantly reduced nitric oxide reactivity, klf2a reporter expression, vascular mural cell number and TRPV4 expression, while significantly increasing spontaneous neuronal activation and GFAP expression (all in the optic tectum). Furthermore, when we examined larval behaviour we found glucose exposure significantly altered light/dark preference and high and low speed locomotion while in light. Co-treatment with SNP reversed all these molecular and behavioural effects of glucose exposure.Our findings comprehensively describe the negative effects of glucose exposure on the vascular anatomy, molecular phenotype, and function of the optic tectum and on whole organism behaviour. We also show that SNP or other NO donors may represent a therapeutic strategy to ameliorate the complications of diabetes on the neurovascular unit.

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Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm

Cited by 47 publications

References 29 publications

Antidepressant and Antiamnesic Potential of Foeniculum vulgare

Antidepressant and Antiamnesic Potential of Foeniculum vulgare

SETD1B controls cognitive function via cell type specific regulation of neuronal identity genes

Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish

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