Unpublished Neuropathologic Mechanism Behind the Muscle Weakness/Paralysis and Gait Disturbances Induced by Sciatic Nerve Degeneration After Spinal Subarachnoid Hemorrhage: An Experimental Study

Kılıç, Mustafa; Aydın, Mehmet Dumlu; Demirci, Elif; Kılıç, Betül; Yılmaz, İlhan; Tanrıverdi, Osman; Kanat, Ayhan

doi:10.1016/j.wneu.2018.08.054

Cited by 30 publications

(17 citation statements)

References 32 publications

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“…SAH is a devastating neurologic emergency, 20 and RD is an important complication of SAH that causes loss of vision. We described the relationship of RD after SAH in a rabbit model and found that the severity of RD was inversely related to the neuronal density of the PPG and directly related to the degree of vasospasm in the ophthalmic artery, suggesting that vasospasm may contribute to RD after aneurysmal SAH.…”

Section: Interpretation Of the Resultsmentioning

confidence: 99%

“…We know the calculation of sample size is one of the most important components of the design of experimental rabbit SAH studies. 20,54 If a researcher selects fewer animals, it may lead to missing any significant difference even if it exists in the population and if the number of animals selected then may lead to an unnecessary waste of resources and possibly ethical issues. 54 Many researchers consider six animals per group as an adequate sample size, but after reviewing the available literature on this issue, we concluded that this notion of six animals per group has little scientific and statistical basis.…”

Section: Limitationsmentioning

confidence: 99%

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Describing a New Mechanism of Retinal Detachment Secondary to Ophthalmic Artery Vasospasm Following Subarachnoid Hemorrhage: An Experimental Study

Fındık

Kanat

Aydın

et al. 2019

J Neurol Surg A Cent Eur Neurosurg

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Background The pterygopalatine ganglion (PPG) and ophthalmic arteries (OpAs) have important roles in ocular autoregulation and retinal and visual functions. The relationship between PPG neuron density, OpA vasospasm, and retinal detachment in subarachnoid hemorrhage (SAH) has never been studied. Methods This study was conducted on 25 rabbits. Five animals were in the control group (GI; n = 5), five in the sham group (GII; n = 5), and 15 in the study group (GIII; n = 15). After injection of 1 cc serum saline into the cisterna magna in the sham group, and autologous blood in the SAH group, the animals were followed for 3 weeks. All animals underwent a retinal examination five times a week for 3 weeks before and after the experiment. After the experiment, the neuron density of PPGs of the facial nerves, vasospasm index (VSI) of OpAs, and total basal surface values of the detached retinal parts (DRPs) were calculated. Results In the funduscopic examination, intravitreous hemorrhage ( Terson's syndrome) was detected in four animals in the SAH group. In the control groups, neuron density was 12,000 ± 1,240/mm3, VSI = 0.345 ± 0.076, and DRP = 0 to 1.5 mm2. Mean neuron density was 9,450 ± 940/mm3, VSI = 1.645 ± 0.940, and DRP = 6.23 ± 1.61 mm2 in the sham group (p < 0.05). Neuron density was 6,890 ± 932/mm3, VSI = 2.92 ± 0.97, and DRP = 9.43 ± 2.54 mm2 in SAH group. Conclusion Mean neuron density, VSI of OpAs, and DRP values differed statistically significant between the SAH group and other groups (p < 0.005). There is an inverse relationship between PPG neurons and DRP. However, a direct relationship was observed between the mean VSI and DRP values.

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Section: Interpretation Of the Resultsmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Describing a New Mechanism of Retinal Detachment Secondary to Ophthalmic Artery Vasospasm Following Subarachnoid Hemorrhage: An Experimental Study

Fındık

Kanat

Aydın

et al. 2019

J Neurol Surg A Cent Eur Neurosurg

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“…Несмотря на то что седалищный нерв отвечает за значительную часть иннервации тазовых конечностей, данные о его состоянии при патологии спинного мозга остаются очень скудными и разрозненными. Так, при моделировании субарахноидального кровоизлияния на уровне L 1 уже на 14-е сут отмечают патологические изменения в седалищном нерве: возрастает численная плотность дегенерированных аксонов и наблюдается их набухание [28]. При моделировании контузионного повреждения спинного мозга на пояснично-крестцовом уровне (Th 13 /L 1 ) на 42-е сут наблюдают значительное уменьшение диаметра аксонов (на 21-31 %) и толщины миелина нервных волокон (на 20-28 %) большеберцового и общего малоберцового нервов.…”

Section: Discussionunclassified

Morphological changes in the sciatic nerve in experimental modeling of contusion injury of the spinal cord in rats

2021

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Objective. To analyze morphological and morphometric changes in the sciatic nerve of rats after the spinal cord injury.Material and Methods. The Т9 moderately severe contusion injury of the spinal cord was simulated in 12 Wistar female rats. Functions of the pelvic limbs were assessed according to the standardized BBB scale. The animals were withdrawn from the experiment after nine and 13 weeks. Epoxy semi-thin (1 µm) sections were used to study sciatic nerve at the light-optical level.Results. Significant recovery of pelvic limb functions was observed within four weeks after surgery, the plateau was achieved by Week 5 (9.5 ± 0.28 points according to the BBB scale), the deterioration in the motor activity was observed by Week 9 (8.67 ± 0.33), its recovery was achieved by Week 13 of the experiment (9.5 ± 0.87). After 9 and 13 weeks, reactive-destructive changes were detected in the sciatic nerve in 9 % and 8 % of nerve conductors, an increase in the number density of myelin fibers by 28 % and 27 % (p < 0.05) and myelin-free fibers by 20 % and 49 % (p < 0.05), and a decrease in axon diameters by 8 % and 10 % (p < 0.05), respectively.Conclusions. The morphological and morphometric changes in the sciatic nerve revealed after the spinal cord injury in the form of destruction of a part of the fibers, axonal atrophy and a decrease in the proportion of large fibers negatively affect its conductive properties. The leveling of peripheral nerve damage, possibly, will accelerate the regression of the motor deficit caused by the spinal cord injury; therefore, it is necessary to develop a set of preventive measures aimed at preventing the reorganization of the peripheral nerve tissue.

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“…We think that our results should be validated in more studies, and this study will lead to more studies in this subject. We know that the calculation of sample size is one of the important components of the design of a study [35]. If a researcher selects fewer cases, it may lead to missing any signi cant difference even if it exists in the population [36].…”

Section: Limitationsmentioning

confidence: 99%

Indirect Evidence of Increased Cerebral Plasticity of Musicians with Malignant Cerebral Tumors; Longer Overall Survival Status according to Nonmusicians

Gasenzer¹,

Kanat

Özdemi̇r

et al. 2021

Preprint

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Background There are some reported musicians with cerebral tumors, but no comparative study of the survival status of musician and nonmusician patients with malignant cerebral tumors was made. This subject was investigated. Material and methods Musician people list with cerebral tumors was searched from the English Wikipedia (https://en.wikipedia.org/wiki/List_of_people_with_brain_tumors). Their survival status, ages, and gender were statistically compared with 30 nonmusician patients with cerebral malign tumors. Results 66 (Group 1 or Musician Group; MG) musicians with malignant tumors list were found from Wikipedia. Survival times of only 47 musicians could be reached from Wikipedia. The mean Survival of this group is 20.06 months, however, it was 13.10 months non-musician group, and the difference of survival was statistically significant (p < 0.05), however, ages and gender were not. Conclusion There is an interaction between music and brain anatomic structures. Our study showed that the survival status of musicians and non-musician with malign cerebral tumors is not the same. This result may be dependent on the altered musician's brain or neuronal plasticity, and the response of the musician's brain's to malign tumor. More studies are needed.

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Unpublished Neuropathologic Mechanism Behind the Muscle Weakness/Paralysis and Gait Disturbances Induced by Sciatic Nerve Degeneration After Spinal Subarachnoid Hemorrhage: An Experimental Study

Cited by 30 publications

References 32 publications

Describing a New Mechanism of Retinal Detachment Secondary to Ophthalmic Artery Vasospasm Following Subarachnoid Hemorrhage: An Experimental Study

Describing a New Mechanism of Retinal Detachment Secondary to Ophthalmic Artery Vasospasm Following Subarachnoid Hemorrhage: An Experimental Study

Morphological changes in the sciatic nerve in experimental modeling of contusion injury of the spinal cord in rats

Indirect Evidence of Increased Cerebral Plasticity of Musicians with Malignant Cerebral Tumors; Longer Overall Survival Status according to Nonmusicians

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