“…Metabolite 115 inhibited the accumulation of the pro-inflammatory iNOS protein of LPS-stimulated RAW264.7 macrophage cells at 50 μM [41]. Four new cembranoid diterpenes, 11,12-epoxy-1(E),3(E),7(E)-cembratrien-15-ol (117), 3,4:11,12-diepoxy-15-methoxy-1(E),7(E)-cembradiene (118), 1(E),3(E),7(E),11(E)-cembratetraene-14,15-diol (119), and 3,14-epoxy-1(E),7(E),11(E)-cembratriene-4,15-diol (120), have been isolated from the soft coral Sinularia gibberosa [42]. A series of analogs were isolated from the soft coral Sinularia flexibilis (121) [43], Sinularia gibberosa (122) [44], Sarcophyton decaryi (123,124) [45,46], Nephthea brassica (125) [47], Lobopbytum pauciflorum (126)(127) [20,48], Sarcophyton mililatensis (130) [49].…”