Marine soft corals as source of lead compounds for anti-inflammatories

Putra, Masteria Yunovilsa; Murniasih, Tutik

doi:10.12980/jclm.4.2016j5-226

Cited by 4 publications

(8 citation statements)

References 29 publications

(28 reference statements)

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“…Inflammation is a pathological condition that represents a part of our immune system response to harmful stimuli, eg, irritants, injured cells, and pathogens. 1 Recently, a variety of appalling chronic diseases have been proven to be associated with inflammation, such as rheumatoid arthritis, 2 atherosclerosis, 3 diabetes, 4 Alzheimer's, 5 inflammatory bowel disease, 6 and cancer. 7 Inflammatory processes usually involve several cell types encompassing neutrophils, basophils, eosinophils, and mononuclear cells (eg, monocytes and macrophages).…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] Some pro-and anti-inflammatory mediators are also commonly produced during inflammation, including cytokines, chemokines, tumor necrosis factor-α, and inducible enzymes, such as cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS), which play some key regulatory roles. 1,11 Therefore, different mechanisms and mediators implicated in painful and inflammatory states have been the focus of numerous recent studies. 12 Additionally, in spite of the available arsenal of anti-inflammatory agents, typically represented by glucocorticoids, nonsteroidal anti-inflammatory drugs, and immunosuppressants, the therapy seems to be not effective enough and is also constrained by many undesired side effects, [13][14][15] deepening the need for discovering other new anti-inflammatory drug candidates.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral Nephthea Sp. Supported by Metabolomics Analysis and Docking Studies

Abdelhafez

Ali

Fahim

et al. 2020

IJN

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Background: Soft corals have been endorsed as a plentiful source of bioactive compounds with promising anti-inflammatory activities; therefore, exploring their potential as source of anti-inflammatory metabolites has stimulated a growing research interest. Purpose: To investigate the anti-inflammatory potential of the soft coral, Nephthea sp., in its bulk and silver nanostructure. Metabolomics analysis of Nephthea sp., followed by molecular docking studies, was also conducted in order to explore and predict the secondary metabolites that might provide its inhibitory actions on inflammation. Materials and Methods: The petroleum ether and ethyl acetate fractions were used to synthesize silver nanoparticles. The prepared silver nanoparticles were characterized through UV-vis spectrophotometric, transmission electron microscopy (TEM) and Fourier-transform infrared spectroscopy (FTIR) analyses. Testing for the anti-inflammatory activity was performed against COX-1 and COX-2. Furthermore, liquid chromatography-mass spectrometry (LC-MS) based metabolomics analysis and molecular docking were also applied. Results: A variety of secondary metabolites were identified, among them, sesquiterpenes were found to prevail. The petroleum ether and acetone fractions of Nephthea sp. showed the highest COX-2 inhibitory activities, possibly attributable to their substantial contents of terpenoids. Additionally, the green synthesized silver nanoparticles of both the petroleum ether and ethyl acetate fractions of Nephthea sp. demonstrated higher anti-COX-2 properties. Conclusion: The obtained results showed the effectiveness of non-targeted metabolomics technique in metabolic profiling of Nephthea sp., helping the search for new bioactive metabolites in future chemical studies on this soft coral. The interesting anti-inflammatory potential of the tested extracts and their nanoparticles could also be relevant to the development of new, effective anti-inflammatory agents.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral Nephthea Sp. Supported by Metabolomics Analysis and Docking Studies

Abdelhafez

Ali

Fahim

et al. 2020

IJN

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“…A known steroid, which was identified as 5,6-epoxylitosterol (48), was obtained from the octocoral Litophyton columnaris. The compound significantly inhibited the generation of superoxide anion generation and the release of elastase, with IC50 values of 4.60 μM and 3.90 μM, respectively [95].…”

Section: Sterolsmentioning

confidence: 99%

Unlocking the Potential of Octocoral-Derived Secondary Metabolites against Neutrophilic Inflammatory Response

Nguyen,

El-Shazly,

Chen

et al. 2023

Marine Drugs

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Inflammation is a critical defense mechanism that is utilized by the body to protect itself against pathogens and other noxious invaders. However, if the inflammatory response becomes exaggerated or uncontrollable, its original protective role is not only demolished but it also becomes detrimental to the affected tissues or even to the entire body. Thus, regulating the inflammatory process is crucial to ensure that it is resolved promptly to prevent any subsequent damage. The role of neutrophils in inflammation has been highlighted in recent decades by a plethora of studies focusing on neutrophilic inflammatory diseases as well as the mechanisms to regulate the activity of neutrophils during the overwhelmed inflammatory process. As natural products have demonstrated promising effects in a wide range of pharmacological activities, they have been investigated for the discovery of new anti-inflammatory therapeutics to overcome the drawbacks of current synthetic agents. Octocorals have attracted scientists as a plentiful source of novel and intriguing marine scaffolds that exhibit many pharmacological activities, including anti-inflammatory effects. In this review, we aim to provide a summary of the neutrophilic anti-inflammatory properties of these marine organisms that were demonstrated in 46 studies from 1995 to the present (April 2023). We hope the present work offers a comprehensive overview of the anti-inflammatory potential of octocorals and encourages researchers to identify promising leads among numerous compounds isolated from octocorals over the past few decades to be further developed into anti-inflammatory therapeutic agents.

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“…Half of the review publications focused on the chemical diversity of specific genera, such as Xenia [ 10 ], Cespitularia [ 11 ], Alcyonium [ 12 ], Sacrophyton [ 13 ], Sinularia [ 14 , 15 ], and Lobophytum [ 14 ], or on a particular species, e.g., Sinularia flexibilis [ 16 , 17 ]. Several reviews showed their interests in a limited type of secondary metabolites—mainly cembranoids [ 14 ], steroids [ 18 , 19 ], and terpenoids [ 10 , 12 , 14 , 20 ]—or in compounds exhibiting certain bioactivities, such as anti-inflammatory metabolites [ 21 , 22 ]. Overall, the similarity of these publications was that the soft corals were mentioned in general, whether they were wild types or were harvested from cultivation.…”

Section: Aquaculture Backgroundmentioning

confidence: 99%

Towards Sustainable Medicinal Resources through Marine Soft Coral Aquaculture: Insights into the Chemical Diversity and the Biological Potential

et al. 2022

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In recent decades, aquaculture techniques for soft corals have made remarkable progress in terms of conditions and productivity. Researchers have been able to obtain larger quantities of soft corals, thus larger quantities of biologically active metabolites, allowing them to study their biological activity in many pharmacological assays and even produce sufficient quantities for clinical trials. In this review, we summarize 201 secondary metabolites that have been identified from cultured soft corals in the era from 2002 to September 2022. Various types of diterpenes (eunicellins, cembranes, spatanes, norcembranes, briaranes, and aquarianes), as well as biscembranes, sterols, and quinones were discovered and subjected to bioactivity investigations in 53 different studies. We also introduce a more in-depth discussion of the potential biological effects (anti-cancer, anti-inflammatory, and anti-microbial) and the mechanisms of action of the identified secondary metabolites. We hope this review will shed light on the untapped potential applications of aquaculture to produce valuable secondary metabolites to tackle current and emerging health conditions.

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Marine soft corals as source of lead compounds for anti-inflammatories

Cited by 4 publications

References 29 publications

<p>Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral <em>Nephthea</em> Sp. Supported by Metabolomics Analysis and Docking Studies</p>

<p>Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral <em>Nephthea</em> Sp. Supported by Metabolomics Analysis and Docking Studies</p>

Unlocking the Potential of Octocoral-Derived Secondary Metabolites against Neutrophilic Inflammatory Response

Towards Sustainable Medicinal Resources through Marine Soft Coral Aquaculture: Insights into the Chemical Diversity and the Biological Potential

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