Unpaarigkeit und Radikalketten im Reaktionsmechanismus organischer und enzymatischer Vorgänge

Haber, F.; Willstätter, Richard

doi:10.1002/cber.19310641118

Cited by 242 publications

(45 citation statements)

References 27 publications

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“…1). However, the reduction of oxygen is frequently incomplete, and a series of reactive chemical intermediates, free radicals, are produced [21,22]. These free radicals attack the double bonds in poly unsaturated fatty acids (PUFA) initiating an autocatalytic chain reaction, known as lipid peroxidation [23,24] (Fig.…”

Section: Resultsmentioning

confidence: 99%

Erythrocyte membrane fatty acid profile in patients with primary carcinoma of the gallbladder

Pandey

Khatri

Dubey

et al. 1995

Journal of Surgical Oncology

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Erythrocyte fatty acids were determined in patients with gall stones and carcinoma of the gallbladder. Significantly low levels of myristic acid (P < 0.01) and stearic acid (P < 0.001) and significantly high levels of palmitoleic acid (P < 0.05) and oleic acid (P < 0.01) were observed in cancer patients. Arachidonic and linolenic acid were significantly high in gallstone patients, but there was no significant difference in the lauric acid and palmitic acid levels. Thus an altered lipid metabolism in cancer patients suggest existence of a possible association between gallstones, fatty acids, and carcinoma of the gallbladder.

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Section: Resultsmentioning

confidence: 99%

Erythrocyte membrane fatty acid profile in patients with primary carcinoma of the gallbladder

Pandey

Khatri

Dubey

et al. 1995

Journal of Surgical Oncology

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“…After Fenton (100) discovered that Fe(II) catalyzed the oxidation of tartaric acid by hydrogen peroxide, it was proposed that hydroxyl radicals, hydrogen peroxide, and superoxide anions undergo a chain reaction that results in a net conversion of hydrogen peroxide into water (119,120). This became known as the Haber-Weiss reaction and is now believed to be at the core of much ROS generation in cells.…”

Section: A Mitochondrial Free Radical Productionmentioning

confidence: 99%

Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals

Hulbert¹,

Pamplona²,

Buffenstein

et al. 2007

Physiological Reviews

750

725

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Maximum life span differences among animal species exceed life span variation achieved by experimental manipulation by orders of magnitude. The differences in the characteristic maximum life span of species was initially proposed to be due to variation in mass-specific rate of metabolism. This is called the rate-of-living theory of aging and lies at the base of the oxidative-stress theory of aging, currently the most generally accepted explanation of aging. However, the rate-of-living theory of aging while helpful is not completely adequate in explaining the maximum life span. Recently, it has been discovered that the fatty acid composition of cell membranes varies systematically between species, and this underlies the variation in their metabolic rate. When combined with the fact that 1) the products of lipid peroxidation are powerful reactive molecular species, and 2) that fatty acids differ dramatically in their susceptibility to peroxidation, membrane fatty acid composition provides a mechanistic explanation of the variation in maximum life span among animal species. When the connection between metabolic rate and life span was first proposed a century ago, it was not known that membrane composition varies between species. Many of the exceptions to the rate-of-living theory appear explicable when the particular membrane fatty acid composition is considered for each case. Here we review the links between metabolic rate and maximum life span of mammals and birds as well as the linking role of membrane fatty acid composition in determining the maximum life span. The more limited information for ectothermic animals and treatments that extend life span (e.g., caloric restriction) are also reviewed.

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“…The other reaction that is closely related to the Fenton reaction is HaberWeiss reaction [83,84]. It was firstly described (in German) by Haber and Willstätter in 1931 [85], secondly demonstrated its kinetics by Baxendale et al in 1946 [86] and experimentally verified that hydroxyl radical is produced from an interaction between hydrogen peroxide and superoxide anion by Weiss in 1949 [87]. This reaction indeed enlightens the toxicity of superoxide anion to generate a detrimental ROS, hydroxyl radical.…”

Section: Increased Ros Productionmentioning

confidence: 98%

Oxidative Stress in Urolithiasis

Boonla¹

2018

Reactive Oxygen Species (ROS) in Living Cells

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Oxygen is absolutely essential for the survival of our life. However, metabolic consumption of oxygen inevitably yields reactive oxygen species (ROS). Imbalance of ROS production and antioxidant capacity causes oxidative stress that potentially damages biomolecules leading to cell injury and death. In fact, ROS have two-faceted functions. Under physiologic condition, ROS function as signaling molecules and participate in maintaining redox balance. In pathology, ROS induce oxidative stress that critically involves in the development of several diseases including urolithiasis (UL). UL or urinary stone disease is a common urologic condition in all countries with progressively increasing prevalence. Most of UL are multifactorial with polygenic susceptibility and highly recurrent nature. Formation of urinary stones is driven by supersaturation of urinary lithogenic ions, and calcium oxalate (CaOx) is the most prevalent stone type. Oxidative stress clearly plays an active role in UL development. In vitro, lithogenic crystals induce ROS generation in renal tubular cells leading to oxidative stress, cell injury and release of inflammatory mediators. In nephrolithic rats, oxidative stress and CaOx deposit are gradually increased in the rats' kidneys. Intervention with antioxidants efficiently reduces oxidative damage and crystal deposits. Human studies show that patients with UL have increased oxidative stress and renal tubular injury relative to the non-stone-forming individuals. Increased oxidative lesions and inflammation are observed in the stone-containing kidneys of the patients. Furthermore, renal fibrosis mediated through tubular epithelial-mesenchymal transition is observed in kidneys of stone patients. Increased renal fibrosis is significantly associated with decreased kidney function. From therapeutic point of view, nutraceutical regimens that are able to reduce oxidative stress may be clinically useful alternatives for preventing stone formation and recurrence. This chapter has an intention to provide a basic knowledge of ROS generation and oxidative stress and up-to-date research findings of oxidative stress in UL based on the published articles as well as the author's studies.

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Unpaarigkeit und Radikalketten im Reaktionsmechanismus organischer und enzymatischer Vorgänge

Cited by 242 publications

References 27 publications

Erythrocyte membrane fatty acid profile in patients with primary carcinoma of the gallbladder

Erythrocyte membrane fatty acid profile in patients with primary carcinoma of the gallbladder

Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals

Oxidative Stress in Urolithiasis

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