Unmet Needs for a Rapid Diagnosis of Chikungunya Virus Infection

Abstract

Rapid Diagnosis of Chikungunya Virus Infection

Diagnosis of Chikungunya by a Rapid Immunochromatographic Method in a Tertiary Care Setting

“…Other factors such as heterophile antibodies or rheumatoid factors can confuse the result. (Blacksell et al, 2011;Rianthavorn et al, 2010;Burdino et al, 2016).…”

Dilemma in laboratory diagnosis of Dengue, Chikungunya and Zika viruses

“…The sensitivity of these tests evaluated by Burdino et al in settings with a high prevalence of CHIKV infection is poor (range 1.9%-50.8%) compared with that for reference assays, especially in the acute phase of disease. 53 Recently, Rapid Diagnostic Test (RDT) kit for detecting IgG/IgM antibodies against Zika virus (Zika IgG/IgM RDT kit) has been developed by Kim et al and proved to be effective in the field. The diagnostic accuracy of Zika RDT was fairly high; sensitivity and specificity for IgG was 99.0 and 99.3%, respectively, while for IgM it was 96.7 and 98.7%, respectively.…”

Evaluation of a Newly Developed Rapid Automated Fluorescent Lateral Flow Immunoassay to Detect IgG and IgM Antibodies to Chikungunya Virus

“…Cinical course is usually mild and self-limited [ 7 ]. But as symptoms are not specific and difficult to distinguish from other similar viral infection (such as dengue and Zika virus), the diagnosis cannot be solely confirmed on clinical findings and laboratory diagnosis is essential [ 8 ].…”

“…RT-PCR is most sensitive assay for early phase infection, but limited due to short viremia. For sera collected after 5 days of onset, serodiagnosis is more accurate indicator of disease [ 8 ]. Serum IgM detection is available from 5 days to several months after symptom onset and IgG antibodies are detected after 4 - 10 days after symptom onset and persisted for years [ 10 ].…”

“…Point-of-care (POC) assays are now available for detecting anti-CHIKV antibodies and recommended to facilitate outbreak control [ 8 ]. Especially, travelers returning from endemic areas changes the epidemiology of CHIKV infection nowadays [ 10 ].…”