Unlocking the potential of vaccines built on messenger RNA

Dolgin, Elie

doi:10.1038/d41586-019-03072-8

Cited by 11 publications

(11 citation statements)

References 10 publications

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“…While clinical development of RNA therapeutics has faced decades of significant challenges in terms of potency and immunogenicity, in recent years, the field has gained some momentum with the recent approval of two siRNA-based drugs patisiran and givosiran [ 15 , 16 ] within a short period of time. This, combined with a well-filled clinical pipeline of mRNA therapeutics [ 17 ], shows the potential of clinical development of RNA therapeutics in the coming years. Because of the rapid developments in this field, this review focuses specifically on RNA therapeutics, its delivery, challenges, and finally, the outlook on clinical applications.…”

Section: Current Landscape Of Biopharmaceutical Industrymentioning

confidence: 99%

Paving the Road for RNA Therapeutics

Dammes

Peer

2020

Trends in Pharmacological Sciences

163

152

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Therapeutic RNA molecules possess high potential for treating medical conditions if they can successfully reach the target cell upon administration. However, unmodified RNA molecules are rapidly degraded and cleared from the circulation. In addition, their large size and negative charge complicates their passing through the cell membrane. The difficulty of RNA therapy, therefore, lies in the efficient intracellular delivery of intact RNA molecules to the tissue of interest without inducing adverse effects. Here, we outline the recent developments in therapeutic RNA delivery and discuss the wide potential in manipulating the function of cells with RNAs. The focus is not only on the variety of delivery strategies but also on the versatile nature of RNA and its wide applicability. This wide applicability is especially interesting when considering the modular nature of nucleic acids. An optimal delivery vehicle, therefore, can facilitate numerous clinical applications of RNA.

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Section: Current Landscape Of Biopharmaceutical Industrymentioning

confidence: 99%

Paving the Road for RNA Therapeutics

Dammes

Peer

2020

Trends in Pharmacological Sciences

163

152

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“…mRNA vaccines are an emerging new vaccine modality in which patients are treated with mRNA oligonucleotides that encode either an antigen of interest or an antigen as well as its viral replication machinery 144 . The potential advantages of the mRNA approach to prophylactic vaccines include the ability to mimic natural infection to stimulate a more potent immune response, combining multiple mRNAs into a single vaccine, rapid discovery to respond to emerging pandemic threats and manufacturing agility derived from the platform nature of mRNA vaccine design and production 145 .…”

Section: The Current Pipeline For Sars-cov-2 Vaccinesmentioning

confidence: 99%

COVID-19: Progress in diagnostics, therapy and vaccination

Liu¹,

Liu²,

Liu³

et al. 2020

Theranostics

135

107

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Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently become a pandemic. As the sudden emergence and rapid spread of SARS-CoV-2 is endangering global health and the economy, the development of strategies to contain the virus's spread are urgently needed. At present, various diagnostic kits to test for SARS-CoV-2 are available for use to initiate appropriate treatment faster and to limit further spread of the virus. Several drugs have demonstrated in vitro activity against SARS-CoV-2 or potential clinical benefits. In addition, institutions and companies worldwide are working tirelessly to develop treatments and vaccines against COVID-19. However, no drug or vaccine has yet been specifically approved for COVID-19. Given the urgency of the outbreak, we focus here on recent advances in the diagnostics, treatment, and vaccine development for SARS-CoV-2 infection, helping to guide strategies to address the current COVID-19 pandemic.

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“…Pharmaceutical companies have been studying and developing mRNA vaccines to specifically target proteins on tumor cells, allowing human immune cells to recognize and then destroy malignant cells. 31,32 In the case of targeted cancer therapy, it is not widely available because the immunotherapy must be custom made for each tumor due to the various mutations cancer cells employ to evade the immune system. The principle of this therapy has already been used to develop vaccines against other coronaviruses, such as MERS and SARS, but these vaccines were not manufactured on a global scale because the diseases never reached pandemic proportions.…”

Section: Feared Complications Of Covid-19 Vaccinationmentioning

confidence: 99%

COVID-19 vaccination: an attempt to control the pandemic

Armin¹,

Wakil²,

Tarbox³

et al. 2021

The Chronicles

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Background: Since the Severe Acute Respiratory Syndrome Coronavirus-2 was discovered in December 2019, there have been tireless efforts by the medical and scientific community to understand its pathophysiology, treatment, and prevention. Discussion: In the last several months, several therapeutic treatments, including a corticosteroid, antiviral drugs, convalescent plasma, and several others, have been tried in the treatment of SARS-CoV-2 with varying results. Pfizer and Moderna COVID-19 vaccines recently received approval for Emergency Use Authorization. Although COVID-19 vaccine is the first hurdle in an attempt to control the pandemic, the following challenges still remain: adequate vaccine doses, issues with mass distribution, global access, proper storage, and sufficient vaccine compliance. Summary: Vaccination, in addition to social distancing and wearing facemasks, will likely provide the best way to control the COVID pandemic. Healthcare professionals and government officials will need to address any concern or hesitancy the community has with the COVID vaccine to promote compliance. Keywords: coronavirus therapeutics, herd immunity, coronavirus vaccine, vaccine targets, clinical trials

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Unlocking the potential of vaccines built on messenger RNA

Cited by 11 publications

References 10 publications

Paving the Road for RNA Therapeutics

Paving the Road for RNA Therapeutics

COVID-19: Progress in diagnostics, therapy and vaccination

COVID-19 vaccination: an attempt to control the pandemic

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