Unleashing the Canine Genome

Ostrander, Elaine A.; Kruglyak, Leonid

doi:10.1101/gr.155900

Cited by 129 publications

(93 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The breeding potential for males is much larger than that for females because a bitch will rarely raise more than one litter per year, while a single male could father a large number of litters. This has resulted in the existence of ''popular sires'' (Ostrander and Kruglyak 2000), dogs that because of their characteristics have been often used as breeders. Some of these males may produce .100 litters in their lifetime (Ostrander and Kruglyak 2000).…”

Section: Discussionmentioning

confidence: 99%

Unequal Contribution of Sexes in the Origin of Dog Breeds

et al. 2006

View full text Add to dashboard Cite

Dogs (Canis familiaris) were domesticated from the gray wolf (Canis lupus) at least 14,000 years ago, and there is evidence of dogs with phenotypes similar to those in modern breeds 4000 years ago. However, recent genetic analyses have suggested that modern dog breeds have a much more recent origin, probably ,200 years ago. To study the origin of contemporaneous breeds we combined the analysis of paternally inherited Y chromosome markers with maternally inherited mitochondrial DNA and biparentally inherited autosomal microsatellite markers in both domestic dogs and their wild ancestor, the gray wolf. Our results show a sex bias in the origin of breeds, with fewer males than females contributing genetically, which clearly differs from the breeding patterns in wild gray wolf populations where both sexes have similar contributions. Furthermore, a comparison of mitochondrial DNA and Y chromosome diversity in dog groups recognized by the World Canine Organization, as well as in groups defined by the breeds' genetic composition, shows that paternal lineages are more differentiated among groups than maternal lineages. This demonstrates a lower exchange of males than of females between breeds belonging to different groups, which illustrates how breed founders may have been chosen.

show abstract

Section: Discussionmentioning

confidence: 99%

Unequal Contribution of Sexes in the Origin of Dog Breeds

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Polymorphism and haplotype structure in the domestic dog The modern dog has a distinct population structure with hundreds of genetically isolated breeds, widely varying disease incidence and distinctive morphological and behavioural traits 89,90 . Unlocking the full potential of the dog genome for genetic analysis requires a dense SNP map and an understanding of the structure of genetic variation both within and among breeds.…”

Section: Genesmentioning

confidence: 99%

“…They have not undergone such recent severe bottlenecks, but some lines have lost diversity because of the repeated use of popular sires 89 . The Glen of Imaal terrier represents the opposite end of the popularity spectrum, with fewer than 100 new puppies registered with the American kennel Club each year.…”

Section: Genesmentioning

confidence: 99%

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Lindblad‐Toh¹,

Wade²,

Mikkelsen³

et al. 2005

Nature

Self Cite

2,224

2,079

View full text Add to dashboard Cite

Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

show abstract

“…In the past decade, Canis familiaris has emerged as an excellent system for genetic analysis of complex phenotypes. Most of the advantages offered by the canine system over other mammalian systems derive from its population structure (Ostrander and Kruglyak 2000;Sutter et al 2004;Parker and Ostrander 2005;Goldstein et al 2006;Karlsson et al 2007;Parker et al 2007). There are .350 distinct breeds recognized in the world today, many of which are isolates that have been, for the most part, selected for morphology and behavior.…”

mentioning

confidence: 99%

Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes

Jones¹,

Chase

Martin³

et al. 2008

Genetics

139

168

View full text Add to dashboard Cite

Phenotypic stereotypes are traits, often polygenic, that have been stringently selected to conform to specific criteria. In dogs, Canis familiaris, stereotypes result from breed standards set for conformation, performance (behaviors), etc. As a consequence, phenotypic values measured on a few individuals are representative of the breed stereotype. We used DNA samples isolated from 148 dog breeds to associate SNP markers with breed stereotypes. Using size as a trait to test the method, we identified six significant quantitative trait loci (QTL) on five chromosomes that include candidate genes appropriate to regulation of size (e.g., IGF1, IGF2BP2 SMAD2, etc.). Analysis of other morphological stereotypes, also under extreme selection, identified many additional significant loci. Less well-documented data for behavioral stereotypes tentatively identified loci for herding, pointing, boldness, and trainability. Four significant loci were identified for longevity, a breed characteristic not under direct selection, but inversely correlated with breed size. The strengths and limitations of the approach are discussed as well as its potential to identify loci regulating the within-breed incidence of specific polygenic diseases.

show abstract

Unleashing the Canine Genome

Cited by 129 publications

References 17 publications

Unequal Contribution of Sexes in the Origin of Dog Breeds

Unequal Contribution of Sexes in the Origin of Dog Breeds

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes

Contact Info

Product

Resources

About